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Characteristics and Timing of Initial Virus Shedding in Severe Acute Respiratory Syndrome Coronavirus 2, Utah, USA.
Emerg Infect Dis ; 27(2): 352-359, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-961594
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1. Specimen Collection TREATS Patients
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Specimen Collection
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TREATS
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Patients
2. 2019 novel coronavirus PROCESS_OF Patients
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2019 novel coronavirus
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Patients
3. Specimen Collection TREATS Patients
Subject
Specimen Collection
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TREATS
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Patients
4. 2019 novel coronavirus PROCESS_OF Patients
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2019 novel coronavirus
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ABSTRACT
Virus shedding in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can occur before onset of symptoms; less is known about symptom progression or infectiousness associated with initiation of viral shedding. We investigated household transmission in 5 households with daily specimen collection for 5 consecutive days starting a median of 4 days after symptom onset in index patients. Seven contacts across 2 households implementing no precautionary measures were infected. Of these 7, 2 tested positive for SARS-CoV-2 by reverse transcription PCR on day 3 of 5. Both had mild, nonspecific symptoms for 1-3 days preceding the first positive test. SARS-CoV-2 was cultured from the fourth-day specimen in 1 patient and from the fourth- and fifth-day specimens in the other. We also describe infection control measures taken in the households that had no transmission. Persons exposed to SARS-CoV-2 should self-isolate, including from household contacts, wear a mask, practice hand hygiene, and seek testing promptly.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Shedding / Disease Transmission, Infectious / Environmental Exposure / SARS-CoV-2 / COVID-19 Limits: Adolescent / Adult / Child / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: Emerg Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Shedding / Disease Transmission, Infectious / Environmental Exposure / SARS-CoV-2 / COVID-19 Limits: Adolescent / Adult / Child / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: Emerg Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article