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Cutting Edge: Severe SARS-CoV-2 Infection in Humans Is Defined by a Shift in the Serum Lipidome, Resulting in Dysregulation of Eicosanoid Immune Mediators.
Schwarz, Benjamin; Sharma, Lokesh; Roberts, Lydia; Peng, Xiaohua; Bermejo, Santos; Leighton, Ian; Casanovas-Massana, Arnau; Minasyan, Maksym; Farhadian, Shelli; Ko, Albert I; Dela Cruz, Charles S; Bosio, Catharine M.
  • Schwarz B; Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840.
  • Sharma L; Section of Pulmonary and Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT 06520.
  • Roberts L; Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840.
  • Peng X; Section of Pulmonary and Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT 06520.
  • Bermejo S; Section of Pulmonary and Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT 06520.
  • Leighton I; Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840.
  • Casanovas-Massana A; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06520; and.
  • Minasyan M; Section of Pulmonary and Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT 06520.
  • Farhadian S; Section of Infectious Diseases, Department of Medicine, Yale University School of Medicine, New Haven, CT 06520.
  • Ko AI; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06520; and.
  • Dela Cruz CS; Section of Pulmonary and Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT 06520; charles.delacruz@yale.edu bosioc@niaid.nih.gov.
  • Bosio CM; Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840; charles.delacruz@yale.edu bosioc@niaid.nih.gov.
J Immunol ; 206(2): 329-334, 2021 01 15.
Article in English | MEDLINE | ID: covidwho-961742
ABSTRACT
The COVID-19 pandemic has affected more than 20 million people worldwide, with mortality exceeding 800,000 patients. Risk factors associated with severe disease and mortality include advanced age, hypertension, diabetes, and obesity. Each of these risk factors pathologically disrupts the lipidome, including immunomodulatory eicosanoid and docosanoid lipid mediators (LMs). We hypothesized that dysregulation of LMs may be a defining feature of the severity of COVID-19. By examining LMs and polyunsaturated fatty acid precursor lipids in serum from hospitalized COVID-19 patients, we demonstrate that moderate and severe disease are separated by specific differences in abundance of immune-regulatory and proinflammatory LMs. This difference in LM balance corresponded with decreased LM products of ALOX12 and COX2 and an increase LMs products of ALOX5 and cytochrome p450. Given the important immune-regulatory role of LMs, these data provide mechanistic insight into an immuno-lipidomic imbalance in severe COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Eicosanoids / Lipidomics / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Immunol Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Eicosanoids / Lipidomics / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Immunol Year: 2021 Document Type: Article