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Exploring the real-world effect of the SARS-CoV-2 pandemic on the molecular diagnostics for cancer patients and high-risk individuals.
Cavic, Milena; Krivokuca, Ana; Boljevic, Ivana; Spasic, Jelena; Mihajlovic, Milica; Pavlovic, Marijana; Damjanovic, Ana; Radosavljevic, Davorin; Jankovic, Radmila.
  • Cavic M; Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.
  • Krivokuca A; Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.
  • Boljevic I; Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.
  • Spasic J; Clinic for Medical Oncology, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.
  • Mihajlovic M; Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.
  • Pavlovic M; Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.
  • Damjanovic A; Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.
  • Radosavljevic D; Clinic for Medical Oncology, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.
  • Jankovic R; Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.
Expert Rev Mol Diagn ; 21(1): 101-107, 2021 01.
Article in English | MEDLINE | ID: covidwho-962282
ABSTRACT

Background:

The SARS-CoV-2 pandemic introduced a global distraction effect in cancer patients' care. The aim of this study was to explore the effect of the pandemic on the largest molecular diagnostics center for cancer patients and high-risk individuals in Serbia.Research design and

methods:

EGFR, KRAS/NRAS, BRAF, and BRCA1/2 mutation testing were performed by qPCR and NGS. NGS was used for panel testing of hereditary breast/ovarian cancer and cancers associated with Lynch syndrome. The analytical output during the state of emergency (SoE) was compared to the period before and after the outbreak using one-way ANOVA. Statistical significance was set at p < 0.05.

Results:

A 38% reduction in the number of analysis was detected during the SoE. After the SoE, a 19% reduction was noted compared to SoE and 50% compared to the period before the SoE (p = 0.038). Three of the 48 scheduled appointments for pretest genetic counseling were carried out during the SoE, but the number of NGS tests increased by 50%.

Conclusions:

The SARS-CoV-2 pandemic had a profound negative effect on the diagnostic output of our centralized molecular diagnostics center. The only positive effect was shortening of waiting lists for hereditary cancer patients and high-risk individuals.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ovarian Neoplasms / Breast Neoplasms / Colorectal Neoplasms, Hereditary Nonpolyposis / Mutation Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Female / Humans Country/Region as subject: Europa Language: English Journal: Expert Rev Mol Diagn Journal subject: Molecular Biology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ovarian Neoplasms / Breast Neoplasms / Colorectal Neoplasms, Hereditary Nonpolyposis / Mutation Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Female / Humans Country/Region as subject: Europa Language: English Journal: Expert Rev Mol Diagn Journal subject: Molecular Biology Year: 2021 Document Type: Article