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COVID-19, Antiphospholipid Antibodies, and Catastrophic Antiphospholipid Syndrome: A Possible Association?
El Hasbani, Georges; Taher, Ali T; Jawad, Ali; Uthman, Imad.
  • El Hasbani G; Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
  • Taher AT; Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
  • Jawad A; Department of Rheumatology, The Royal London Hospital, Bancroft Road, London, UK.
  • Uthman I; Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Clin Med Insights Arthritis Musculoskelet Disord ; 13: 1179544120978667, 2020.
Article in English | MEDLINE | ID: covidwho-962351
ABSTRACT
Since the 2019 novel coronavirus (COVID-19) was first detected in December 2019, research on the complications and fatality of this virus has hastened. Initially, case reports drew an association between COVID-19 and abnormal coagulation parameters. Subsequently, cross-sectional studies found a high prevalence of thrombosis among ICU and non-ICU COVID-19 patients. For that reason, certain studies tried to explain the pathogenic mechanisms of thrombosis, one of which was the emergence of anti-phospholipid antibodies (aPL). Although aPL have been found positive in very few patients, their association with thrombotic events stays debatable. Given the thrombotic manifestations of COVID-19 and the potential role of aPL, the catastrophic form of APS (CAPS) might be a major fatal phenomenon. However, to date, there has been no clear association of CAPS to COVID-19. Moreover, since infections, including viral respiratory similar to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are considered main etiologies for CAPS, it could be possible that SARS-CoV-2 can induce CAPS although no evidence is currently found. High quality studies are needed to develop a clear idea on the pathogenic role of aPL in the progression of thrombosis in COVID-19 patients, and how such patients could be fit into a thromboprophylaxis plan.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Observational study / Randomized controlled trials Language: English Journal: Clin Med Insights Arthritis Musculoskelet Disord Year: 2020 Document Type: Article Affiliation country: 1179544120978667

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Observational study / Randomized controlled trials Language: English Journal: Clin Med Insights Arthritis Musculoskelet Disord Year: 2020 Document Type: Article Affiliation country: 1179544120978667