The Impact of Dementia on the Clinical Outcome of COVID-19: A Systematic Review and Meta-Analysis.
J Alzheimers Dis
; 78(4): 1775-1782, 2020.
Article
in English
| MEDLINE | ID: covidwho-963307
ABSTRACT
BACKGROUND:
The emergence of the coronavirus disease 2019 (COVID-19) has brought large challenges to dementia patients. We reviewed the existing literature on COVID-19 to assess the incidence and mortality of dementia comorbidities in COVID-19 patients.OBJECTIVE:
To investigate the impact of pre-existing dementia comorbidities on COVID-19.METHODS:
We searched the PubMed, Embase, and Web of Science databases for patients with preexisting dementia who were diagnosed with COVID-19. The statistical data on the prevalence and mortality of dementia comorbidities were examined. A fixed-or random-effect model was used to calculate the overall pooled risk estimates. Forest plots were generated to show the summarized results.RESULTS:
A total of 265 articles were retrieved from the three databases. After removing duplicates and performing two screenings, 10 articles were selected for meta-analysis, including 119,218 participants. Overall, the meta-analysis of the 10 studies showed that the incidence of dementia in COVID-19 patients was (R 9%, [95% CI 6% to 13%]). Moreover, the meta-analysis of 9 studies showed that the mortality rate of individuals with dementia after being infected with COVID-19 was higher than that of individuals with no dementia (OR 5.17 [95% CI 2.31 to 11.59]). Substantial heterogeneity was observed in this meta-analysis. Significant publication bias was also found.CONCLUSION:
Emerging literature shows that dementia comorbidities are a high risk factor for the prevalence and mortality of COVID-19. Our results should have an impact on preventive interventions and encourage more targeted approaches to prioritize older people with specific risk factors, such as dementia.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Dementia
/
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
/
Reviews
/
Systematic review/Meta Analysis
Topics:
Long Covid
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
J Alzheimers Dis
Journal subject:
Geriatrics
/
Neurology
Year:
2020
Document Type:
Article
Affiliation country:
Jad-201016
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