Nitazoxanide against COVID-19 in three explorative scenarios.
J Infect Dev Ctries
; 14(9): 982-986, 2020 09 30.
Article
in English
| MEDLINE | ID: covidwho-963457
ABSTRACT
INTRODUCTION:
Nitazoxanide has shown efficacy in vitro against coronavirus infections (MERS, SARS, SARS-CoV-2). The aim of this report is to describe the results of treating COVID-19 positive patients with nitazoxanide in three clinical settings pregnancy/puerperium, hospitalized patients in an Internal Medicine Service and in an ambulatory setting.METHODOLOGY:
This was a prospective follow-up and report of COVID-19 cases in three different situations, pregnant women, hospitalized patients receiving medical attention in an Internal Medicine Service and ambulatory patients residing in Toluca City, and Mexico City.RESULTS:
The experience with a first group of 20 women, pregnant (17) or in immediate puerperium (3) was successful in 18 cases with two unfortunate deaths. The five cases treated in an Internal Medicine service showed a positive outcome with two patients weaned from mechanical ventilation. Of the remaining 16 patients treated in an ambulatory setting, all got cured. Nitazoxanide seems to be useful against SARS-CoV-2, not only in an early intervention but also in critical condition as well as in pregnancy without undesired effects for the babies. As an adjunctive therapy budesonide was used that seems to contribute to the clinical improvement.CONCLUSIONS:
Nitazoxanide could be useful against COVID-19 as a safe and available regimen to be tested in a massive way immediately.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Pneumonia, Viral
/
Thiazoles
/
Coronavirus Infections
/
Betacoronavirus
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Limits:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
Country/Region as subject:
Mexico
Language:
English
Journal:
J Infect Dev Ctries
Journal subject:
Communicable Diseases
Year:
2020
Document Type:
Article
Affiliation country:
JIDC.13274
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