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Identifying side effects of commonly used drugs in the treatment of Covid 19.
Aygün, Irfan; Kaya, Mehmet; Alhajj, Reda.
  • Aygün I; Department of Software Engineering, Celal Bayar University, Manisa, Turkey.
  • Kaya M; Department of Computer Engineering, Firat University, Elazig, Turkey.
  • Alhajj R; Department of Computer Science, University of Calgary, Calgary, AB, Canada. rsalhajj@gmail.com.
Sci Rep ; 10(1): 21508, 2020 12 09.
Article in English | MEDLINE | ID: covidwho-965423
ABSTRACT
To increase the success in Covid 19 treatment, many drug suggestions are presented, and some clinical studies are shared in the literature. There have been some attempts to use some of these drugs in combination. However, using more than one drug together may cause serious side effects on patients. Therefore, detecting drug-drug interactions of the drugs used will be of great importance in the treatment of Covid 19. In this study, the interactions of 8 drugs used for Covid 19 treatment with 645 different drugs and possible side effects estimates have been produced using Graph Convolutional Networks. As a result of the experiments, it has been found that the hematopoietic system and the cardiovascular system are exposed to more side effects than other organs. Among the focused drugs, Heparin and Atazanavir appear to cause more adverse reactions than other drugs. In addition, as it is known that some of these 8 drugs are used together in Covid-19 treatment, the side effects caused by using these drugs together are shared. With the experimental results obtained, it is aimed to facilitate the selection of the drugs and increase the success of Covid 19 treatment according to the targeted patient.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Heparin / Atazanavir Sulfate / SARS-CoV-2 / COVID-19 / COVID-19 Drug Treatment Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-78697-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Heparin / Atazanavir Sulfate / SARS-CoV-2 / COVID-19 / COVID-19 Drug Treatment Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-78697-1