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Anti-SARS-Cov-2 IgA Response in Tears of COVID-19 Patients.
Caselli, Elisabetta; Soffritti, Irene; Lamberti, Giuseppe; D'Accolti, Maria; Franco, Filippo; Demaria, Davide; Contoli, Marco; Passaro, Angela; Contini, Carlo; Perri, Paolo.
  • Caselli E; Department of Chemical and Pharmaceutical Sciences and LTTA, Section of Microbiology, University of Ferrara, 44121 Ferrara, Italy.
  • Soffritti I; Department of Chemical and Pharmaceutical Sciences and LTTA, Section of Microbiology, University of Ferrara, 44121 Ferrara, Italy.
  • Lamberti G; Department of Biomedical and Surgical-Specialized Sciences, Ophthalmology Unit, University of Ferrara, 44121 Ferrara, Italy.
  • D'Accolti M; Department of Chemical and Pharmaceutical Sciences and LTTA, Section of Microbiology, University of Ferrara, 44121 Ferrara, Italy.
  • Franco F; Department of Biomedical and Surgical-Specialized Sciences, Ophthalmology Unit, University of Ferrara, 44121 Ferrara, Italy.
  • Demaria D; Department of Biomedical and Surgical-Specialized Sciences, Ophthalmology Unit, University of Ferrara, 44121 Ferrara, Italy.
  • Contoli M; Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy.
  • Passaro A; Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy.
  • Contini C; Department of Medical Sciences, Infectious Diseases Unit, University of Ferrara, 44121 Ferrara, Italy.
  • Perri P; Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy.
Biology (Basel) ; 9(11)2020 Nov 03.
Article in English | MEDLINE | ID: covidwho-965887
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Eye LOCATION_OF Present
Subject
Eye
Predicate
LOCATION_OF
Object
Present
3. Body Fluids PART_OF conjunctiva
Subject
Body Fluids
Predicate
PART_OF
Object
conjunctiva
4. Body Fluids LOCATION_OF Antibodie
Subject
Body Fluids
Predicate
LOCATION_OF
Object
Antibodie
5. Body Fluids PART_OF Patients
Subject
Body Fluids
Predicate
PART_OF
Object
Patients
6. Enzyme-Linked Immunosorbent Assay METHOD_OF Schirmer tear test procedure
Subject
Enzyme-Linked Immunosorbent Assay
Predicate
METHOD_OF
Object
Schirmer tear test procedure
7. Eye LOCATION_OF COVID-19
Subject
Eye
Predicate
LOCATION_OF
Object
COVID-19
8. anti-IgA|CD79A|LOC102723407 PART_OF 2019 novel coronavirus
Subject
anti-IgA|CD79A|LOC102723407
Predicate
PART_OF
Object
2019 novel coronavirus
9. Detection USES immunoglobulin
Subject
Detection
Predicate
USES
Object
immunoglobulin
10. Eye LOCATION_OF anti-IgA|CD79A|LOC102723407
Subject
Eye
Predicate
LOCATION_OF
Object
anti-IgA|CD79A|LOC102723407
11. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
12. Eye LOCATION_OF Present
Subject
Eye
Predicate
LOCATION_OF
Object
Present
13. Body Fluids PART_OF conjunctiva
Subject
Body Fluids
Predicate
PART_OF
Object
conjunctiva
14. Body Fluids LOCATION_OF Antibodies, Anti-Idiotypic
Subject
Body Fluids
Predicate
LOCATION_OF
Object
Antibodies, Anti-Idiotypic
15. Body Fluids PART_OF Patients
Subject
Body Fluids
Predicate
PART_OF
Object
Patients
16. Enzyme-Linked Immunosorbent Assay METHOD_OF Schirmer tear test procedure
Subject
Enzyme-Linked Immunosorbent Assay
Predicate
METHOD_OF
Object
Schirmer tear test procedure
17. Eye LOCATION_OF COVID-19
Subject
Eye
Predicate
LOCATION_OF
Object
COVID-19
18. anti-IgA|CD79A|LOC102723407 PART_OF 2019 novel coronavirus
Subject
anti-IgA|CD79A|LOC102723407
Predicate
PART_OF
Object
2019 novel coronavirus
19. Detection USES immunoglobulin A, human
Subject
Detection
Predicate
USES
Object
immunoglobulin A, human
20. Eye LOCATION_OF anti-IgA|CD79A|LOC102723407
Subject
Eye
Predicate
LOCATION_OF
Object
anti-IgA|CD79A|LOC102723407
ABSTRACT
The pandemic virus SARS-CoV-2 has been reported to be able to enter the body via the eye conjunctiva, but the presence of antiviral response in the eye remains poorly known. Our study was thus aimed to analyze the presence of secretory mucosal anti-SARS-CoV-2 type A immunoglobulins (IgA) in the conjunctival fluid of COVID-19 patients. The tears of 28 COVID-19 patients and 20 uninfected controls were collected by the Schirmer test and analyzed by a specific ELISA assay detecting anti-spike (S1) virus protein IgA. The results showed that 35.7% of COVID-19 subjects have specific antiviral IgA at the ocular level, persisting till 48 days post disease onset. Most of the IgA positive subjects presented mild symptoms. The collected data indicate a prolonged persistence of anti-SARS-CoV-2 IgA at the eye level and suggest that IgA detection may be extremely helpful in clarifying virus pathology and epidemiology.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Topics: Long Covid Language: English Year: 2020 Document Type: Article Affiliation country: Biology9110374

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Full text: Available Collection: International databases Database: MEDLINE Topics: Long Covid Language: English Year: 2020 Document Type: Article Affiliation country: Biology9110374