Corrected Minute Ventilation Is Associated With Mortality in ARDS Caused by COVID-19.
Respir Care
; 66(4): 619-625, 2021 04.
Article
in English
| MEDLINE | ID: covidwho-966677
ABSTRACT
BACKGROUND:
The ratio of dead space to tidal volume (VD/VT) is associated with mortality in patients with ARDS. Corrected minute ventilation ([Formula see text]) is a simple surrogate of dead space, but, despite its increasing use, its association with mortality has not been proven. The aim of our study was to assess the association between [Formula see text] and hospital mortality. We also compared the strength of this association with that of estimated VD/VT and ventilatory ratio.METHODS:
We performed a retrospective study with prospectively collected data. We evaluated 187 consecutive mechanically ventilated subjects with ARDS caused by novel coronavirus disease (COVID-19). The association between [Formula see text] and hospital mortality was assessed in multivariable logistic models. The same was done for estimated VD/VT and ventilatory ratio.RESULTS:
Mean ± SD [Formula see text] was 11.8 ± 3.3 L/min in survivors and 14.5 ± 3.9 L/min in nonsurvivors (P < .001) and was independently associated with mortality (adjusted odds ratio 1.15, P = .01). The strength of association of [Formula see text] with mortality was similar to that of VD/VT and ventilatory ratio.CONCLUSIONS:
[Formula see text] was independently associated with hospital mortality in subjects with ARDS caused by COVID-19. [Formula see text] could be used at the patient's bedside for outcome prediction and severity stratification, due to the simplicity of its calculation. These findings need to be confirmed in subjects with ARDS without viral pneumonia and when lung-protective mechanical ventilation is not rigorously applied.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiratory Distress Syndrome
/
Coronavirus
/
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Respir Care
Year:
2021
Document Type:
Article
Affiliation country:
Respcare.08314
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