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Impact of chronic liver disease upon admission on COVID-19 in-hospital mortality: Findings from COVOCA study.
Galiero, Raffaele; Pafundi, Pia Clara; Simeon, Vittorio; Rinaldi, Luca; Perrella, Alessandro; Vetrano, Erica; Caturano, Alfredo; Alfano, Maria; Beccia, Domenico; Nevola, Riccardo; Marfella, Raffaele; Sardu, Celestino; Coppola, Carmine; Scarano, Ferdinando; Maggi, Paolo; De Lucia Sposito, Pellegrino; Vocciante, Laura; Rescigno, Carolina; Sbreglia, Costanza; Fraganza, Fiorentino; Parrella, Roberto; Romano, Annamaria; Calabria, Giosuele; Polverino, Benedetto; Pagano, Antonio; Bologna, Carolina; Amitrano, Maria; Esposito, Vincenzo; Coppola, Nicola; Maturo, Nicola; Adinolfi, Luigi Elio; Chiodini, Paolo; Sasso, Ferdinando Carlo.
  • Galiero R; Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Pafundi PC; Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Simeon V; Medical Statistics Unit, Department of Physical and Mental Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Rinaldi L; Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Perrella A; Task Force Covid-19 Regione Campania, Napoli, Italy.
  • Vetrano E; Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Caturano A; Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Alfano M; Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Beccia D; Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Nevola R; Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Marfella R; Internal Medicine, Sant'Ottone Frangipane Hospital, Ariano Irpino, Italy.
  • Sardu C; Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Coppola C; Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Scarano F; COVID Center "S. Anna e SS. Madonna della Neve" Hospital, Boscotrecase, Italy.
  • Maggi P; COVID Center "S. Anna e SS. Madonna della Neve" Hospital, Boscotrecase, Italy.
  • De Lucia Sposito P; U.O.C. Infectious and Tropical Diseases, S. Anna e S. Sebastiano Hospital, Caserta, Italy.
  • Vocciante L; Covid Center-Maddaloni Hospital, Maddaloni, Italy.
  • Rescigno C; General Medicine Unit, Loreto Mare Hospital, Naples, Italy.
  • Sbreglia C; U.O.C. Infectious Diseases and Neurology, Cotugno Hospital, Naples, Italy.
  • Fraganza F; U.O.C. Infectious Diseases of the Elderly, Cotugno Hospital, Naples, Italy.
  • Parrella R; U.O.C. Anestesia and Intensive Care Unit, Cotugno Hospital, Naples, Italy.
  • Romano A; U.O.C. Respiratory Infectious Diseases, Cotugno Hospital, Naples, Italy.
  • Calabria G; U.O.C. Pneumology, Moscati Hospital, Avellino, Italy.
  • Polverino B; IXth Division of Infectious Diseases and Interventional Ultrasound, Cotugno Hospital, Naples, Italy.
  • Pagano A; "Giovanni da Procida" Hospital, Salerno, Italy.
  • Bologna C; Emergency and Acceptance Unit, "Santa Maria delle Grazie" Hospital, Pozzuoli, Italy.
  • Amitrano M; Internal Medicine Unit, Ospedale Del Mare, Naples, Italy.
  • Esposito V; U.O.C. Internal Medicine-Moscati Hospital, Avellino, Italy.
  • Coppola N; IVth Division of Immunodeficiency and Gender Infectious Diseases, Cotugno Hospital, Naples, Italy.
  • Maturo N; Department of Mental Health and Public Medicine, Centro COVID A.O.U. Vanvitelli, Naples, Italy.
  • Adinolfi LE; U.O.S.D. Infectious Diseases Emergency and Acceptance, Cotugno Hospital, Naples, Italy.
  • Chiodini P; Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Sasso FC; Medical Statistics Unit, Department of Physical and Mental Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
PLoS One ; 15(12): e0243700, 2020.
Article in English | MEDLINE | ID: covidwho-966684
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF hospitalized patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
hospitalized patients
2. COVID-19 PROCESS_OF hospitalized patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
hospitalized patients
ABSTRACT

BACKGROUND:

Italy has been the first Western country to be heavily affected by the spread of SARS-COV-2 infection and among the pioneers of the clinical management of pandemic. To improve the outcome, identification of patients at the highest risk seems mandatory.

OBJECTIVES:

Aim of this study is to identify comorbidities and clinical conditions upon admission associated with in-hospital mortality in several COVID Centers in Campania Region (Italy).

METHODS:

COVOCA is a multicentre retrospective observational cohort study, which involved 18 COVID Centers throughout Campania Region, Italy. Data were collected from patients who completed their hospitalization between March-June 2020. The endpoint was in-hospital mortality, assessed either from data at discharge or death certificate, whilst all exposure variables were collected at hospital admission.

RESULTS:

Among 618 COVID-19 hospitalized patients included in the study, 143 in-hospital mortality events were recorded, with a cumulative incidence of about 23%. At multivariable logistic analysis, male sex (OR 2.63, 95%CI 1.42-4.90; p = 0.001), Chronic Liver Disease (OR 5.88, 95%CI 2.39-14.46; p<0.001) and malignancies (OR 2.62, 95%CI 1.21-5.68; p = 0.015) disclosed an independent association with a poor prognosis, Glasgow Coma Scale (GCS) and Respiratory Severity Scale allowed to identify at higher mortality risk. Sensitivity analysis further enhanced these findings.

CONCLUSION:

Mortality of patients hospitalized for COVID-19 appears strongly affected by both clinical conditions on admission and comorbidities. Originally, we observed a very poor outcome in subjects with a chronic liver disease, alongside with an increase of hepatic damage.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Liver Diseases Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2020 Document Type: Article Affiliation country: Journal.pone.0243700

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Liver Diseases Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2020 Document Type: Article Affiliation country: Journal.pone.0243700