New drug targets for hypertension: A literature review.
Biochim Biophys Acta Mol Basis Dis
; 1867(3): 166037, 2021 03 01.
Article
in English
| MEDLINE | ID: covidwho-966695
ABSTRACT
Hypertension is one of the most prevalent cardiovascular diseases worldwide. However, in the population of resistant hypertension, blood pressure is difficult to control effectively. Moreover, antihypertensive drugs may have adverse effect currently. Hence, new therapeutic targets and treatments are needed to uncovered and exploited to control hypertension and its comorbidities. In the past, classical drug targets, such as the aldosterone receptor, aldosterone synthase, and ACE2/angiotensin 1-7/Mas receptor axis, have been investigated. Recently, vaccines and drugs targeting the gastrointestinal microbiome, which represent drug classes, have also been investigated for the management of blood pressure. In this review, we summarized current knowledge on classical and new drug targets and discussed the potential utility of new drugs in the treatment of hypertension.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Drug Discovery
/
Molecular Targeted Therapy
/
Hypertension
/
Antihypertensive Agents
Type of study:
Prognostic study
/
Reviews
Topics:
Vaccines
Limits:
Animals
/
Humans
Language:
English
Journal:
Biochim Biophys Acta Mol Basis Dis
Year:
2021
Document Type:
Article
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