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Guillain-Barré syndrome associated with SARS-CoV-2 infection: A systematic review and individual participant data meta-analysis.
Hasan, Imran; Saif-Ur-Rahman, K M; Hayat, Shoma; Papri, Nowshin; Jahan, Israt; Azam, Rufydha; Ara, Gulshan; Islam, Zhahirul.
  • Hasan I; Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division, icddr,b, Dhaka, Bangladesh.
  • Saif-Ur-Rahman KM; Health Systems and Population Studies Division, icddr,b, Dhaka, Bangladesh.
  • Hayat S; Department of Public Health and Health Systems, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
  • Papri N; Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division, icddr,b, Dhaka, Bangladesh.
  • Jahan I; Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division, icddr,b, Dhaka, Bangladesh.
  • Azam R; Department of Neurology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • Ara G; Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division, icddr,b, Dhaka, Bangladesh.
  • Islam Z; Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division, icddr,b, Dhaka, Bangladesh.
J Peripher Nerv Syst ; 25(4): 335-343, 2020 12.
Article in English | MEDLINE | ID: covidwho-966993
Semantic information from SemMedBD (by NLM)
1. Severe Acute Respiratory Syndrome COEXISTS_WITH Guillain-Barre Syndrome
Subject
Severe Acute Respiratory Syndrome
Predicate
COEXISTS_WITH
Object
Guillain-Barre Syndrome
2. Syndrome PROCESS_OF Patients
Subject
Syndrome
Predicate
PROCESS_OF
Object
Patients
3. Severe Acute Respiratory Syndrome COEXISTS_WITH Guillain-Barre Syndrome
Subject
Severe Acute Respiratory Syndrome
Predicate
COEXISTS_WITH
Object
Guillain-Barre Syndrome
4. Syndrome PROCESS_OF Patients
Subject
Syndrome
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
Several published reports have described a possible association between Guillain-Barré syndrome (GBS) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. This systematic review aimed to summarize and meta-analyze the salient features and prognosis of SARS-CoV-2-associated GBS. We searched the PubMed (Medline), Web of Science and Cochrane databases for articles published between 01 January 2020 and 05 August 2020 using SARS-CoV-2 and GBS-related keywords. Data on sociodemographic characteristics, antecedent symptoms, clinical, serological and electrophysiological features, and hospital outcomes were recorded. We included 45 articles from 16 countries reporting 61 patients with SARS-CoV-2-associated GBS. Most (97.7%) articles were from high- and upper-middle-income countries. Forty-two (68.9%) of the patients were male; median (interquartile range) age was 57 (49-70) years. Reverse transcriptase polymerase chain reaction for SARS-CoV-2 was positive in 90.2% of patients. One report of SARS-CoV-2-associated familial GBS was found which affected a father and daughter of a family. Albuminocytological dissociation in cerebrospinal fluid was found in 80.8% of patients. The majority of patients (75.5%) had a demyelinating subtype of GBS. Intravenous immunoglobulin and plasmapheresis were given to 92.7% and 7.3% of patients, respectively. Around two-thirds (65.3%) of patients had a good outcome (GBS-disability score ≤ 2) on discharge from hospital. Two patients died in hospital. SARS-CoV-2-associated GBS mostly resembles the classical presentations of GBS that respond to standard treatments. Extensive surveillance is required in low- and lower-middle-income countries to identify and report similar cases/series. Further large-scale case-control studies are warranted to strengthen the current evidence. PROSPERO Registration Number CRD42020201673.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Guillain-Barre Syndrome / COVID-19 Type of study: Observational study / Prognostic study / Reviews / Risk factors / Systematic review Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Peripher Nerv Syst Journal subject: Neurology Year: 2020 Document Type: Article Affiliation country: Jns.12419

Full text: Available Collection: International databases Database: MEDLINE Main subject: Guillain-Barre Syndrome / COVID-19 Type of study: Observational study / Prognostic study / Reviews / Risk factors / Systematic review Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: J Peripher Nerv Syst Journal subject: Neurology Year: 2020 Document Type: Article Affiliation country: Jns.12419