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Vitamin C-An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19.
Holford, Patrick; Carr, Anitra C; Jovic, Thomas H; Ali, Stephen R; Whitaker, Iain S; Marik, Paul E; Smith, A David.
  • Holford P; Institute for Optimum Nutrition, Ambassador House, Richmond TW9 1SQ, UK.
  • Carr AC; Nutrition in Medicine Research Group, Department of Pathology & Biomedical Science, University of Otago, Christchurch 8140, New Zealand.
  • Jovic TH; Reconstructive Surgery & Regenerative Medicine Research Group, Institute of Life Sciences, Swansea University Medical School, Swansea University, Swansea SA2 8PY, UK.
  • Ali SR; Welsh Centre for Burns & Plastic Surgery, Morriston Hospital, Swansea SA6 6NL, UK.
  • Whitaker IS; Reconstructive Surgery & Regenerative Medicine Research Group, Institute of Life Sciences, Swansea University Medical School, Swansea University, Swansea SA2 8PY, UK.
  • Marik PE; Welsh Centre for Burns & Plastic Surgery, Morriston Hospital, Swansea SA6 6NL, UK.
  • Smith AD; Reconstructive Surgery & Regenerative Medicine Research Group, Institute of Life Sciences, Swansea University Medical School, Swansea University, Swansea SA2 8PY, UK.
Nutrients ; 12(12)2020 Dec 07.
Article in English | MEDLINE | ID: covidwho-967092
ABSTRACT
There are limited proven therapies for COVID-19. Vitamin C's antioxidant, anti-inflammatory and immunomodulating effects make it a potential therapeutic candidate, both for the prevention and amelioration of COVID-19 infection, and as an adjunctive therapy in the critical care of COVID-19. This literature review focuses on vitamin C deficiency in respiratory infections, including COVID-19, and the mechanisms of action in infectious disease, including support of the stress response, its role in preventing and treating colds and pneumonia, and its role in treating sepsis and COVID-19. The evidence to date indicates that oral vitamin C (2-8 g/day) may reduce the incidence and duration of respiratory infections and intravenous vitamin C (6-24 g/day) has been shown to reduce mortality, intensive care unit (ICU) and hospital stays, and time on mechanical ventilation for severe respiratory infections. Further trials are urgently warranted. Given the favourable safety profile and low cost of vitamin C, and the frequency of vitamin C deficiency in respiratory infections, it may be worthwhile testing patients' vitamin C status and treating them accordingly with intravenous administration within ICUs and oral administration in hospitalised persons with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ascorbic Acid / Ascorbic Acid Deficiency / Respiratory Tract Infections / Vitamins / Sepsis / COVID-19 Drug Treatment Type of study: Observational study / Reviews Topics: Long Covid Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: Nu12123760

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ascorbic Acid / Ascorbic Acid Deficiency / Respiratory Tract Infections / Vitamins / Sepsis / COVID-19 Drug Treatment Type of study: Observational study / Reviews Topics: Long Covid Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: Nu12123760