Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

Paniz-Mondolfi, Alberto; Bryce, Clare; Grimes, Zachary; Gordon, Ronald E; Reidy, Jason; Lednicky, John; Sordillo, Emilia Mia; Fowkes, Mary

Paniz-Mondolfi, Alberto; Bryce, Clare; Grimes, Zachary; Gordon, Ronald E; Reidy, Jason; Lednicky, John; Sordillo, Emilia Mia; Fowkes, Mary.

Paniz-Mondolfi A; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York.
Bryce C; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York.
Grimes Z; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York.
Gordon RE; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York.
Reidy J; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York.
Lednicky J; Department of Environmental and Global Health, College of Public Health and Health Professions, Emerging Pathogens Institute, University of Florida, Gainesville, Florida.
Sordillo EM; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York.
Fowkes M; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York.

J Med Virol ; 92(7): 699-702, 2020 Jul.

Article in English | MEDLINE | ID: covidwho-96729

ABSTRACT

ABSTRACT

Neurologic sequelae can be devastating complications of respiratory viral infections. We report the presence of virus in neural and capillary endothelial cells in frontal lobe tissue obtained at postmortem examination from a patient infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Our observations of virus in neural tissue, in conjunction with clinical correlates of worsening neurologic symptoms, pave the way to a closer understanding of the pathogenic mechanisms underlying central nervous system involvement by SARS-CoV-2.

Subject(s)

Ageusia/diagnosis; Ataxia/diagnosis; Betacoronavirus/pathogenicity; Coronavirus Infections/diagnosis; Olfaction Disorders/diagnosis; Pneumonia, Viral/diagnosis; Seizures/diagnosis; Aged; Ageusia/complications; Ageusia/physiopathology; Ageusia/virology; Ataxia/complications; Ataxia/physiopathology; Ataxia/virology; Betacoronavirus/genetics; COVID-19; COVID-19 Testing; Clinical Laboratory Techniques/methods; Coronavirus Infections/complications; Coronavirus Infections/physiopathology; Coronavirus Infections/virology; Endothelial Cells/pathology; Endothelial Cells/virology; Fatal Outcome; Frontal Lobe/blood supply; Frontal Lobe/pathology; Frontal Lobe/virology; Hospitalization; Humans; Lung/blood supply; Lung/pathology; Lung/virology; Male; Neurons/pathology; Neurons/virology; Olfaction Disorders/complications; Olfaction Disorders/physiopathology; Olfaction Disorders/virology; Pandemics; Pneumonia, Viral/complications; Pneumonia, Viral/physiopathology; Pneumonia, Viral/virology; RNA, Viral/genetics; Reverse Transcriptase Polymerase Chain Reaction; SARS-CoV-2; Seizures/complications; Seizures/physiopathology; Seizures/virology

Keywords

CNS infection; SARS-CoV-2; endothelium; neuroinvasion; neurotropism

Fulltext

XML

PubMed Links

Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Ataxia / Seizures / Coronavirus Infections / Ageusia / Betacoronavirus / Olfaction Disorders Type of study: Case report / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Language: English Journal: J Med Virol Year: 2020 Document Type: Article

Similar

MEDLINE

LILACS

LIS

Fulltext

XML

PubMed Links

Search on Google