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Absence of relevant QT interval prolongation in not critically ill COVID-19 patients.
Jiménez-Jáimez, Juan; Macías-Ruiz, Rosa; Bermúdez-Jiménez, Francisco; Rubini-Costa, Ricardo; Ramírez-Taboada, Jessica; Flores, Paula Isabel García; Gallo-Padilla, Laura; García, Juan Diego Mediavilla; García, Concepción Morales; Suárez, Sara Moreno; Molina, Celia Fignani; López, Miguel Álvarez; Tercedor, Luis.
  • Jiménez-Jáimez J; Cardiology Department, Virgen de Las Nieves University Hospital, Avenida de las fuerzas armadas 2, 18014, Granada, Spain. jimenez.jaimez@gmail.com.
  • Macías-Ruiz R; Biosanitary Research Institute (IBS), Av. Del conocimiento, 18012, Granada, Spain. jimenez.jaimez@gmail.com.
  • Bermúdez-Jiménez F; Cardiology Department, Virgen de Las Nieves University Hospital, Avenida de las fuerzas armadas 2, 18014, Granada, Spain.
  • Rubini-Costa R; Biosanitary Research Institute (IBS), Av. Del conocimiento, 18012, Granada, Spain.
  • Ramírez-Taboada J; Cardiology Department, Virgen de Las Nieves University Hospital, Avenida de las fuerzas armadas 2, 18014, Granada, Spain.
  • Flores PIG; Biosanitary Research Institute (IBS), Av. Del conocimiento, 18012, Granada, Spain.
  • Gallo-Padilla L; Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 28029, Madrid, Spain.
  • García JDM; Cardiology Department, Virgen de Las Nieves University Hospital, Avenida de las fuerzas armadas 2, 18014, Granada, Spain.
  • García CM; Biosanitary Research Institute (IBS), Av. Del conocimiento, 18012, Granada, Spain.
  • Suárez SM; Cardiology Department, Virgen de Las Nieves University Hospital, Avenida de las fuerzas armadas 2, 18014, Granada, Spain.
  • Molina CF; Biosanitary Research Institute (IBS), Av. Del conocimiento, 18012, Granada, Spain.
  • López MÁ; Department of Internal Medicine, Virgen de Las Nieves University Hospital, Avenida de las fuerzas armadas 2, 18014, Granada, Spain.
  • Tercedor L; Cardiology Department, Virgen de Las Nieves University Hospital, Avenida de las fuerzas armadas 2, 18014, Granada, Spain.
Sci Rep ; 10(1): 21417, 2020 12 08.
Article in English | MEDLINE | ID: covidwho-967294
ABSTRACT
SARS-CoV-2 is a rapidly evolving pandemic causing great morbimortality. Medical therapy with hydroxicloroquine, azitromycin and protease inhibitors is being empirically used, with reported data of QTc interval prolongation. Our aim is to assess QT interval behaviour in a not critically ill and not monitored cohort of patients. We evaluated admitted and ambulatory patients with COVID-19 patients with 12 lead electrocardiogram at 48 h after treatment initiation. Other clinical and analytical variables were collected. Statistical analysis was performed to assess the magnitude of the QT interval prolongation under treatment and to identify clinical, analytical and electrocardiographic risk markers of QT prolongation independent predictors. We included 219 patients (mean age of 63.6 ± 17.4 years, 48.9% were women and 16.4% were outpatients. The median baseline QTc was 416 ms (IQR 404-433), and after treatment QTc was prolonged to 423 ms (405-438) (P < 0.001), with an average increase of 1.8%. Most of the patients presented a normal QTc under treatment, with only 31 cases (14.1%) showing a QTc interval > 460 ms, and just one case with QTc > 500 ms. Advanced age, longer QTc basal at the basal ECG and lower potassium levels were independent predictors of QTc interval prolongation. Ambulatory and not critically ill patients with COVID-19 treated with hydroxychloroquine, azithromycin and/or antiretrovirals develop a significant, but not relevant, QT interval prolongation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Protease Inhibitors / Ventricular Fibrillation / Long QT Syndrome / Azithromycin / Hydroxychloroquine Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-78360-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Protease Inhibitors / Ventricular Fibrillation / Long QT Syndrome / Azithromycin / Hydroxychloroquine Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-78360-9