[A poisoned gift].

Jordan, Bertrand

[A poisoned gift]. / Un cadeau empoisonné - Chroniques génomiques.

Jordan, Bertrand.

Jordan B; UMR 7268 ADÉS, Aix-Marseille, Université/EFS/CNRS ; CoReBio PACA, case 901, Parc scientifique de Luminy, 13288 Marseille Cedex 09, France.

Med Sci (Paris) ; 36(12): 1233-1236, 2020 Dec.

Article in French | MEDLINE | ID: covidwho-967320

ABSTRACT

ABSTRACT

GWAS analysis of severe Covid patients implicates a major locus on chromosome 3. The corresponding 50 kb segment appears to originate from Neanderthal/Sapiens crossings, raising interesting evolutionary questions.

Subject(s)

COVID-19/genetics; Chromosomes, Human, Pair 3/genetics; Genetic Loci; Neanderthals/genetics; SARS-CoV-2/pathogenicity; Adaptor Proteins, Signal Transducing/genetics; Adaptor Proteins, Signal Transducing/metabolism; Angiotensin-Converting Enzyme 2/metabolism; Animals; COVID-19/epidemiology; COVID-19/pathology; COVID-19/therapy; Case-Control Studies; Europe/epidemiology; Evolution, Molecular; Genetic Predisposition to Disease; Genome-Wide Association Study; Hominidae/genetics; Humans; Membrane Glycoproteins/genetics; Membrane Glycoproteins/metabolism; Membrane Transport Proteins/genetics; Membrane Transport Proteins/metabolism; Pandemics; Polymorphism, Single Nucleotide; Protein Binding; Receptors, CCR/genetics; Receptors, CXCR6/genetics; SARS-CoV-2/metabolism; Severity of Illness Index

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chromosomes, Human, Pair 3 / Genetic Loci / Neanderthals / SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Limits: Animals / Humans Country/Region as subject: Europa Language: French Journal: Med Sci (Paris) Journal subject: Medicine Year: 2020 Document Type: Article Affiliation country: Medsci

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