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Assessment of serum ferritin as a biomarker in COVID-19: bystander or participant? Insights by comparison with other infectious and non-infectious diseases.
Kappert, Kai; Jahic, Amir; Tauber, Rudolf.
  • Kappert K; Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Jahic A; Labor Berlin - Charité Vivantes GmbH, Berlin, Germany.
  • Tauber R; Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Biomarkers ; 25(8): 616-625, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-967371
Semantic information from SemMedBD (by NLM)
1. Serum LOCATION_OF Ferritin
Subject
Serum
Predicate
LOCATION_OF
Object
Ferritin
2. Ferritin ASSOCIATED_WITH Disease
Subject
Ferritin
Predicate
ASSOCIATED_WITH
Object
Disease
3. Virus CAUSES Disease
Subject
Virus
Predicate
CAUSES
Object
Disease
4. Ferritin ASSOCIATED_WITH Inflammatory disorder
Subject
Ferritin
Predicate
ASSOCIATED_WITH
Object
Inflammatory disorder
5. Disease PROCESS_OF Patients
Subject
Disease
Predicate
PROCESS_OF
Object
Patients
6. Diagnosis USES Ferritin
Subject
Diagnosis
Predicate
USES
Object
Ferritin
7. Clinical Management USES Ferritin
Subject
Clinical Management
Predicate
USES
Object
Ferritin
8. Ferritin ASSOCIATED_WITH Communicable Diseases
Subject
Ferritin
Predicate
ASSOCIATED_WITH
Object
Communicable Diseases
9. Ferritin ASSOCIATED_WITH Noncommunicable Diseases
Subject
Ferritin
Predicate
ASSOCIATED_WITH
Object
Noncommunicable Diseases
10. Ferritin TREATS hospitalized patients
Subject
Ferritin
Predicate
TREATS
Object
hospitalized patients
11. Serum LOCATION_OF Ferritin
Subject
Serum
Predicate
LOCATION_OF
Object
Ferritin
12. Ferritin ASSOCIATED_WITH Disease
Subject
Ferritin
Predicate
ASSOCIATED_WITH
Object
Disease
13. Virus CAUSES Disease
Subject
Virus
Predicate
CAUSES
Object
Disease
14. Ferritin ASSOCIATED_WITH Inflammatory disorder
Subject
Ferritin
Predicate
ASSOCIATED_WITH
Object
Inflammatory disorder
15. Disease PROCESS_OF Patients
Subject
Disease
Predicate
PROCESS_OF
Object
Patients
16. Diagnosis USES Ferritin
Subject
Diagnosis
Predicate
USES
Object
Ferritin
17. Clinical Management USES Ferritin
Subject
Clinical Management
Predicate
USES
Object
Ferritin
18. Ferritin ASSOCIATED_WITH Communicable Diseases
Subject
Ferritin
Predicate
ASSOCIATED_WITH
Object
Communicable Diseases
19. Ferritin ASSOCIATED_WITH Noncommunicable Diseases
Subject
Ferritin
Predicate
ASSOCIATED_WITH
Object
Noncommunicable Diseases
20. Ferritin TREATS hospitalized patients
Subject
Ferritin
Predicate
TREATS
Object
hospitalized patients
ABSTRACT

BACKGROUND:

The 2019 coronavirus disease (COVID-19) caused by the SARS-CoV-2 virus has an impact on all aspects of patient care. Serum ferritin generally represents a biomarker of choice when iron deficiency is suspected. However, ferritin is also an acute-phase-protein exhibiting elevated serum concentration in various inflammatory diseases. Here we focus on the role of serum ferritin for diagnostic and clinical management of patients with COVID-19 in comparison with other infectious and non-infectious diseases.

METHODS:

We examined scientific articles listed in PubMed reporting on ferritin in various infectious and non-infectious diseases. We then compared these results with nine current COVID-19 ferritin reports published in 2020.

RESULTS:

Several non-infectious, as well as non-COVID-19 infectious diseases, are characterised by a partly dramatic elevation of serum ferritin levels. All COVID-19 studies published between February and May 2020, which documented laboratory serum ferritin, indicate ferritin as a biomarker of COVID-19 severity in hospitalised patients.

CONCLUSIONS:

Serum ferritin may be considered both a prognostic and stratifying biomarker that can also contribute to therapeutic decision-making concerning patients with COVID-19. It should be emphasised, however, that most scientific reports refer to cohorts in the Asian region. Further validation in other cohorts is urgently required.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Biomarkers / Communicable Diseases / Ferritins / COVID-19 / Inflammation Subject: Biomarkers / Communicable Diseases / Ferritins / COVID-19 / Inflammation Type of study: Prognostic study Language: English Journal: Biomarkers Clinical aspect: Diagnosis / Prognosis Year: 2020

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Biomarkers / Communicable Diseases / Ferritins / COVID-19 / Inflammation Subject: Biomarkers / Communicable Diseases / Ferritins / COVID-19 / Inflammation Type of study: Prognostic study Language: English Journal: Biomarkers Clinical aspect: Diagnosis / Prognosis Year: 2020
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