Coronavirus Disease 2019: Virology and Drug Targets.
Infect Disord Drug Targets
; 21(8): e160921188929, 2021.
Article
in English
| MEDLINE | ID: covidwho-967560
ABSTRACT
The Coronavirus Disease 2019, a pandemic caused by novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is seriously affecting global health and the economy. As the vaccine development takes time, the current research is focused on repurposing FDA approved drugs against the viral target proteins. This review discusses the current understanding of SARSCoV- 2 virology, its target structural proteins (S-glycoprotein), non-structural proteins (3-chymotrypsin- like protease, papain-like protease, RNA-dependent RNA polymerase, and helicase) and accessory proteins, drug discovery strategies (drug repurposing, artificial intelligence, and high- -throughput screening), and the current status of antiviral drug development.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pharmaceutical Preparations
/
COVID-19
Topics:
Vaccines
Limits:
Humans
Language:
English
Journal:
Infect Disord Drug Targets
Journal subject:
Communicable Diseases
/
Drug Therapy
Year:
2021
Document Type:
Article
Affiliation country:
1871526520666201209145302
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