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Coronavirus Disease 2019: Virology and Drug Targets
Infectious Disorders Drug Targets ; 09:09, 2020.
Article in English | MEDLINE | ID: covidwho-967560
ABSTRACT
The Coronavirus Disease 2019, a pandemic caused by novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is seriously affecting global health and the economy. As the vaccine development takes time, the current research is focused on repurposing FDA approved drugs against the viral target proteins. This review discusses the current understanding of SARS-CoV-2 virology, its target structural proteins (S- glycoprotein), non-structural proteins (3- chymotrypsin-like protease, papain-like protease, RNA-dependent RNA polymerase, and helicase) and accessory proteins, drug discovery strategies (drug repurposing, artificial intelligence, and high-throughput screening), and the current status of antiviral drug development.

Full text: Available Collection: Databases of international organizations Database: MEDLINE Topics: Vaccines Language: English Journal: Infectious Disorders Drug Targets Year: 2020 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: MEDLINE Topics: Vaccines Language: English Journal: Infectious Disorders Drug Targets Year: 2020 Document Type: Article