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Maturation of T and B Lymphocytes in the Assessment of the Immune Status in COVID-19 Patients.
Kwiecien, Iwona; Rutkowska, Elzbieta; Klos, Krzysztof; Wiesik-Szewczyk, Ewa; Jahnz-Rózyk, Karina; Rzepecki, Piotr; Chcialowski, Andrzej.
  • Kwiecien I; Laboratory of Hematology and Flow Cytometry, Department of Internal Medicine and Hematology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
  • Rutkowska E; Laboratory of Hematology and Flow Cytometry, Department of Internal Medicine and Hematology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
  • Klos K; Department of Infectious Diseases and Allergology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
  • Wiesik-Szewczyk E; Department of Internal Medicine, Pulmonology, Allergology and Clinical Immunology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
  • Jahnz-Rózyk K; Department of Internal Medicine, Pulmonology, Allergology and Clinical Immunology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
  • Rzepecki P; Department of Internal Medicine and Hematology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
  • Chcialowski A; Department of Infectious Diseases and Allergology, Military Institute of Medicine, Szaserów 128, 04-141 Warsaw, Poland.
Cells ; 9(12)2020 12 05.
Article in English | MEDLINE | ID: covidwho-967600
ABSTRACT
Cell response to novel coronavirus disease 19 (COVID-19) is currently a widely researched topic. The assessment of leukocytes population and the maturation of both B and T lymphocytes may be important in characterizing the immunological profile of COVID-19 patients. The aim of the present study was to evaluate maturation of B and T cells in COVID-19 patients with interstitial lesions on chest X-ray (COVID-19 X-ray (+)), without changes on X-ray (COVID-19 X-ray (-)) and in healthy control. The study group consisted of 23 patients divided on two groups COVID-19 X-ray (+) n = 14 and COVID-19 X-ray (-) n = 9 and control n = 20. The flow cytometry method was performed. We observed a significantly higher percentage of plasmablasts and lower CD4+ lymphocytes in COVID-19 X-ray (+) patients than in COVID-19 X-ray (-) and control. In the COVID-19 X-ray (+) patients, there was a lower proportion of effector CD4+ T cells, naïve CD8+ T cells and higher central memory CD4+ cells and effector CD8+ T cells than control. The above results showed that the assessment of selected cells of B and T lymphocytes by flow cytometry can distinguish patients with COVID-19 and differentiate patients with and without changes on chest X-ray.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: B-Lymphocytes / CD4-Positive T-Lymphocytes / CD8-Positive T-Lymphocytes / COVID-19 Type of study: Experimental Studies / Observational study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Year: 2020 Document Type: Article Affiliation country: Cells9122615

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Full text: Available Collection: International databases Database: MEDLINE Main subject: B-Lymphocytes / CD4-Positive T-Lymphocytes / CD8-Positive T-Lymphocytes / COVID-19 Type of study: Experimental Studies / Observational study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Year: 2020 Document Type: Article Affiliation country: Cells9122615