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Effects of inhaled nitric oxide in COVID-19-induced ARDS - Is it worthwhile?
Lotz, Christopher; Muellenbach, Ralf M; Meybohm, Patrick; Mutlak, Haitham; Lepper, Philipp M; Rolfes, Caroline-Barbara; Peivandi, Asghar; Stumpner, Jan; Kredel, Markus; Kranke, Peter; Torje, Iuliu; Reyher, Christian.
  • Lotz C; Department of Anaesthesiology and Critical Care Medicine, University of Würzburg, Würzburg, Germany.
  • Muellenbach RM; Department of Critical Care, Emergency Medicine and Anaesthesiology, ARDS/ECMO-Center, University of Southampton, Kassel, Germany.
  • Meybohm P; Department of Anaesthesiology and Critical Care Medicine, University of Würzburg, Würzburg, Germany.
  • Mutlak H; Department of Anaesthesiology, Intensive Care and Emergency Medicine, Sana Klinikum Offenbach, Kassel, Germany.
  • Lepper PM; Department of Internal Medicine V-Pulmonology, Allergology and Critical Care Medicine, Saarland University, Homburg, Germany.
  • Rolfes CB; Department of Critical Care, Emergency Medicine and Anaesthesiology, ARDS/ECMO-Center, University of Southampton, Kassel, Germany.
  • Peivandi A; Department of Cardiovascular Surgery, ARDS/ECMO-Center, University of Southampton, Kassel, Germany.
  • Stumpner J; Department of Anaesthesiology and Critical Care Medicine, University of Würzburg, Würzburg, Germany.
  • Kredel M; Department of Anaesthesiology and Critical Care Medicine, University of Würzburg, Würzburg, Germany.
  • Kranke P; Department of Anaesthesiology and Critical Care Medicine, University of Würzburg, Würzburg, Germany.
  • Torje I; Department of Critical Care, Emergency Medicine and Anaesthesiology, ARDS/ECMO-Center, University of Southampton, Kassel, Germany.
  • Reyher C; Department of Critical Care, Emergency Medicine and Anaesthesiology, ARDS/ECMO-Center, University of Southampton, Kassel, Germany.
Acta Anaesthesiol Scand ; 65(5): 629-632, 2021 05.
Article in English | MEDLINE | ID: covidwho-967889
ABSTRACT

BACKGROUND:

Changes in pulmonary hemodynamics and ventilation/perfusion were proposed as hallmarks of Coronavirus disease 2019 (COVID-19)-induced acute respiratory distress syndrome (ARDS). Inhaled nitric oxide (iNO) may overcome these issues and improve arterial oxygenation.

METHODS:

We retrospectively analyzed arterial oxygenation and pulmonary vasoreactivity in seven COVID-19 ARDS patients receiving 20 ppm iNO for 15-30 minutes.

RESULTS:

The inhalation of NO significantly improved oxygenation. All patients with severe ARDS had higher partial pressures of oxygen and reduced pulmonary vascular resistance. Significant changes in pulmonary shunting were not observed.

CONCLUSION:

Overall, iNO could provide immediate help and delay respiratory deterioration in COVID-19-induced moderate to severe ARDS.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / SARS-CoV-2 / COVID-19 Drug Treatment / Nitric Oxide Type of study: Experimental Studies / Observational study Topics: Long Covid Limits: Humans Language: English Journal: Acta Anaesthesiol Scand Year: 2021 Document Type: Article Affiliation country: Aas.13757

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / SARS-CoV-2 / COVID-19 Drug Treatment / Nitric Oxide Type of study: Experimental Studies / Observational study Topics: Long Covid Limits: Humans Language: English Journal: Acta Anaesthesiol Scand Year: 2021 Document Type: Article Affiliation country: Aas.13757