The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor.
Biomater Sci
; 8(23): 6603-6610, 2020 Dec 07.
Article
in English
| MEDLINE | ID: covidwho-968358
ABSTRACT
The effect of the polyanionic polymer of inorganic polyphosphate (polyP) involved in innate immunity on the binding of the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein to the cellular ACE2 receptor was studied. The RBD surface comprises a basic amino acid stretch of four arginine residues which interact with the physiological polyP (polyP40) and polyP3. Subsequently, the interaction of RBD with ACE2 is sensitively inhibited. After the chemical modification of arginine, an increased inhibition by polyP, at a 1 1 molar ratio (polyP RBP), is measured already at 0.1 µg mL-1. Heparin was ineffective. The results suggest a potential therapeutic benefit of polyP against SARS-CoV-2 infection.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Polymers
/
Polyphosphates
/
Spike Glycoprotein, Coronavirus
/
Angiotensin-Converting Enzyme 2
Limits:
Humans
Language:
English
Journal:
Biomater Sci
Year:
2020
Document Type:
Article
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