The evolving obesity challenge: targeting the vagus nerve and the inflammatory reflex in the response.
Pharmacol Ther
; 222: 107794, 2021 06.
Article
in English
| MEDLINE | ID: covidwho-968657
ABSTRACT
Obesity and the metabolic syndrome (MetS), which have reached pandemic proportions significantly increase the risk for type 2 diabetes, cardiovascular disease, and other serious conditions. Recent data with COVID-19 patients indicate that obesity also is a significant risk factor for this novel viral disease and poor outcome of associated critical illness. These findings considerably change the view of obesity as a driver of serious, but slowly-progressing chronic diseases, and emphasize the urgency to explore new therapeutic approaches. Inflammation is a recognized driver of metabolic derangements in obesity and MetS, and a core feature of COVID-19 pathobiology. Recent advances in our understanding of inflammatory regulation have highlighted the role of the nervous system and the vagus nerve-based inflammatory reflex. Current bioelectronic and pharmacological therapeutic explorations centered on the inflammatory reflex offer new approaches for conditions characterized by immune and metabolic dysregulation and for ameliorating the escalating burden of obesity, MetS, and COVID-19.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Vagus Nerve
/
COVID-19
/
Inflammation
/
Obesity
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Pharmacol Ther
Year:
2021
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS