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Association between cardiac troponin I and mortality in patients with COVID-19.
Salvatici, Michela; Barbieri, Barbara; Cioffi, Sara Maria Giulia; Morenghi, Emanuela; Leone, Francesco Paolo; Maura, Federica; Moriello, Giuseppe; Sandri, Maria Teresa.
  • Salvatici M; Laboratory Medicine, Humanitas Clinical and Research Center - IRCCS, Rozzano, Italy.
  • Barbieri B; Laboratory Medicine, Humanitas Clinical and Research Center - IRCCS, Rozzano, Italy.
  • Cioffi SMG; Laboratory Medicine, Humanitas Clinical and Research Center - IRCCS, Rozzano, Italy.
  • Morenghi E; Biostatistic Unit, Humanitas Clinical and Research Center - IRCCS, Rozzano, Italy.
  • Leone FP; Laboratory Medicine, Humanitas Clinical and Research Center - IRCCS, Rozzano, Italy.
  • Maura F; Laboratory Medicine, Humanitas Clinical and Research Center - IRCCS, Rozzano, Italy.
  • Moriello G; Laboratory Medicine, Humanitas Clinical and Research Center - IRCCS, Rozzano, Italy.
  • Sandri MT; Laboratory Medicine, Humanitas Clinical and Research Center - IRCCS, Rozzano, Italy.
Biomarkers ; 25(8): 634-640, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-969132
ABSTRACT

BACKGROUND:

Severe pneumonia is pathological manifestation of Coronavirus Disease 2019 (COVID-19), however complications have been reported in COVID-19 patients with a worst prognosis. Aim of this study was to evaluate the role of high sensitivity cardiac troponin I (hs-TnI) in patients with SARS-CoV-2 infection.

METHODS:

we retrospectively analysed hs-TnI values measured in 523 patients (median age 64 years, 68% men) admitted to a university hospital in Milan, Italy, and diagnosed COVID-19.

RESULTS:

A significant difference in hs-TnI concentrations was found between deceased patients (98 patients) vs discharged (425 patients) [36.05 ng/L IQR 16.5-94.9 vs 6.3 ng/L IQR 2.6-13.9, p < 0.001 respectively]. Hs-TnI measurements were independent predictors of mortality at multivariate analysis adjusted for confounding parameters such as age (HR 1.004 for each 10 point of troponin, 95% CI 1.002-1.006, p < 0.001). The survival rate, after one week, in patients with hs-TnI values under 6 ng/L was 97.94%, between 6 ng/L and the normal value was 90.87%, between the normal value and 40 ng/L was 86.98, and 59.27% over 40 ng/L.

CONCLUSION:

Increase of hs-TnI associated with elevated mortality in patients with COVID-19. Troponin shows to be a useful biomarker of disease progression and worse prognosis in COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Biomarkers / Troponin I / COVID-19 / Hospitalization Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Biomarkers Journal subject: Biochemistry Year: 2020 Document Type: Article Affiliation country: 1354750X.2020.1831609

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Biomarkers / Troponin I / COVID-19 / Hospitalization Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Biomarkers Journal subject: Biochemistry Year: 2020 Document Type: Article Affiliation country: 1354750X.2020.1831609