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SARS-CoV-2 receptor ACE2 is co-expressed with genes related to transmembrane serine proteases, viral entry, immunity and cellular stress.
Wruck, Wasco; Adjaye, James.
  • Wruck W; Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heine University, Moorenstr.5, 40225, Düsseldorf, Germany.
  • Adjaye J; Institute for Stem Cell Research and Regenerative Medicine, Medical Faculty, Heinrich Heine University, Moorenstr.5, 40225, Düsseldorf, Germany. james.adjaye@med.uni-duesseldorf.de.
Sci Rep ; 10(1): 21415, 2020 12 08.
Article in English | MEDLINE | ID: covidwho-970024
ABSTRACT
The COVID-19 pandemic resulting from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which emerged in December 2019 in Wuhan in China has placed immense burden on national economies and global health. At present neither vaccination nor therapies are available. Here, we performed a meta-analysis of RNA-sequencing data from three studies employing human lung epithelial cells. Of these one focused on lung epithelial cells infected with SARS-CoV-2. We aimed at identifying genes co-expressed with angiotensin I converting enzyme 2 (ACE2) the human cell entry receptor of SARS-CoV-2, and unveiled several genes correlated or inversely correlated with high significance, among the most significant of these was the transmembrane serine protease 4 (TMPRSS4). Serine proteases are known to be involved in the infection process by priming the virus spike protein. Pathway analysis revealed virus infection amongst the most significantly correlated pathways. Gene Ontologies revealed regulation of viral life cycle, immune responses, pro-inflammatory responses- several interleukins such as IL6, IL1, IL20 and IL33, IFI16 regulating the interferon response to a virus, chemo-attraction of macrophages, and cellular stress resulting from activated Reactive Oxygen Species. We believe that this dataset will aid in a better understanding of the molecular mechanism(s) underlying COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Serine Endopeptidases / Respiratory Mucosa / Epithelial Cells / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 / Membrane Proteins Type of study: Reviews Topics: Vaccines Limits: Humans Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-78402-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Serine Endopeptidases / Respiratory Mucosa / Epithelial Cells / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 / Membrane Proteins Type of study: Reviews Topics: Vaccines Limits: Humans Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-78402-2