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Thermovaccination - thermoheliox as a stimulator of the immune response. Kinetics of the synthesis of antibodies and C-reactive protein in coronavirus infection.
Varfolomeev, Sergey D; Panin, Alexander A; Bykov, Valeriy I; Tsybenova, Svetlana B; Zhuravel, Sergey V; Ryabokon, Anna M; Utkina, Irina I; Gavrilov, Pavel V; Petrikov, Sergey S; Shogenova, Lyudmila V; Chuchalin, Alexander G.
  • Varfolomeev SD; Institute of Physicochemical Foundations of the Functioning of Neural Network and Artificial Intelligence, Moscow State University, Leninskie Gory, 1-11B, Moscow, 119991, Russia; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina, 4, Moscow, 119334, Russia.
  • Panin AA; LLC "MedTechInnovations", Blagoveshchenskii per, 3-1, 123001, Russia.
  • Bykov VI; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina, 4, Moscow, 119334, Russia.
  • Tsybenova SB; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina, 4, Moscow, 119334, Russia. Electronic address: s.tsybenova@gmail.com.
  • Zhuravel SV; N.V. Sklifosovsky Federal Research Institute of Emergency Medicine, Bol'shaya Sukharevskaya Ploshchad', 3, 129090, Russia.
  • Ryabokon AM; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina, 4, Moscow, 119334, Russia; Department of Chemistry, Moscow State University, Leninskie Gory, 1-11B, Moscow, 119991, Russia.
  • Utkina II; N.V. Sklifosovsky Federal Research Institute of Emergency Medicine, Bol'shaya Sukharevskaya Ploshchad', 3, 129090, Russia.
  • Gavrilov PV; N.V. Sklifosovsky Federal Research Institute of Emergency Medicine, Bol'shaya Sukharevskaya Ploshchad', 3, 129090, Russia.
  • Petrikov SS; N.V. Sklifosovsky Federal Research Institute of Emergency Medicine, Bol'shaya Sukharevskaya Ploshchad', 3, 129090, Russia.
  • Shogenova LV; N.I. Pirogov Russian State National Research Medical University, ul. Ostrovityanova, 1, Moscow, 117997, Russia.
  • Chuchalin AG; N.I. Pirogov Russian State National Research Medical University, ul. Ostrovityanova, 1, Moscow, 117997, Russia.
Chem Biol Interact ; 334: 109339, 2021 Jan 25.
Article in English | MEDLINE | ID: covidwho-970426
ABSTRACT
Clinical trials of thermoheliox application (inhalation with a high-temperature mixture of oxygen and helium, 90 °C) in the treatment of the acute phase of coronavirus infection were conducted. Dynamics of disease development in infected patients (PCR test for the virus) and, dynamics of changes in blood concentration of C-reactive protein, immunoglobulin M, specific immunoglobulin G were studied. High efficiency of thermoheliox in releasing the organism from the virus and stimulating the immune response (thermovaccination effect) was shown. The kinetic model of the process is proposed and analyzed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oxygen / COVID-19 / Helium / Hyperthermia, Induced Type of study: Prognostic study Topics: Vaccines Limits: Adult / Aged / Humans / Middle aged Language: English Journal: Chem Biol Interact Year: 2021 Document Type: Article Affiliation country: J.cbi.2020.109339

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oxygen / COVID-19 / Helium / Hyperthermia, Induced Type of study: Prognostic study Topics: Vaccines Limits: Adult / Aged / Humans / Middle aged Language: English Journal: Chem Biol Interact Year: 2021 Document Type: Article Affiliation country: J.cbi.2020.109339