Subpoblaciones linfocitarias de pacientes venezolanos infectados con SARS-CoV-2

ABSTRACT

The SARS-CoV-2 infection has infected more than 50 million people with the lethality of 3 %-10 % of the cases. In Venezuela, around 95 thousand individuals have been found positive with the lethality of around 1 %. Our study aimed to ascertain the different lymphocyte cell populations, analyze possible prognostic markers, and compare them with the literature. A total of 18 RT-PCR positive patients were analyzed, 12 (5 male) moderate (age range 15-71 years), 6 (4 male) severe (age range 29-50 years), and 100 controls matched by age and gender. Lymphopenia was observed in both groups of patients and the T cell population was the most affected. The memory cell population was decreased with the infection as well as the CD25 cell population. However, young patients with moderate symptoms had the highest values of T lymphocytes and memory cells suggesting a prompt resolution of the infection. In conclusion, the decrease in T lymphocytes and CD25 cells is related to the viral infection and CD45RO is a marker of severity in adult patients. © 2020 Academia Nacional de Medicina. All rights reserved.