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Study of Clinical and Biological Characteristics of Moroccan Covid-19 Patients With and Without Olfactory and/or Gustatory Dysfunction.
Benkirane, Hasnae; Heikel, Jaafar; Laamiri, Fatima Zahra; Bouziani, Amina; Lahmam, Houria; Al-Jawaldeh, Ayoub; El Haloui, Noureddine; Ennibi, Khalid; Akhtar-Khan, Naim; El Fahime, El Mostafa; Obtel, Majdouline; Barkat, Amina; Aguenaou, Hassan.
  • Benkirane H; CNESTEN, Joint Research Unit in Nutrition and Food, Regional Designated Center of Nutrition (AFRA/IAEA), Ibn Tofaïl University, Kenitra, Morocco.
  • Heikel J; Mohammed VI University of Health Sciences, Casablanca, Morocco.
  • Laamiri FZ; Laboratory of Health Sciences and Technology, Higher Institute of Health Sciences of settat, Hassan First University of Settat, Settat, Morocco.
  • Bouziani A; CNESTEN, Joint Research Unit in Nutrition and Food, Regional Designated Center of Nutrition (AFRA/IAEA), Ibn Tofaïl University, Kenitra, Morocco.
  • Lahmam H; CNESTEN, Joint Research Unit in Nutrition and Food, Regional Designated Center of Nutrition (AFRA/IAEA), Ibn Tofaïl University, Kenitra, Morocco.
  • Al-Jawaldeh A; Nutrition, Department of NonCommunicable Diseases and Mental Health World Health Organization (WHO),Regional Office for the Eastern Mediterranean (EMRO), Abdul Razzak Al-Sanhouri, Cairo, Egypt.
  • El Haloui N; CNESTEN, Joint Research Unit in Nutrition and Food, Regional Designated Center of Nutrition (AFRA/IAEA), Ibn Tofaïl University, Kenitra, Morocco.
  • Ennibi K; Center of Virology, Infectious and Tropical Diseases, Mohammed V Military Hospital, Rabat, Morocco.
  • Akhtar-Khan N; Inserm Research Center, U1231 INSERM/UB/AgroSup, Team-Physiology of Nutrition & Toxicology, Faculty of Life Sciences, University Bourgogne Franche-Comté (UBFC), Dijon, France.
  • El Fahime EM; Functional Genomic Platform, UATRS-CNRST, Rabat, Morocco.
  • Obtel M; Laboratory of Community Health, Preventive Medicine and Hygiene, Laboratory of Epidemiology and Clinical Research, Department of Public Heath, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.
  • Barkat A; Health and Nutrition Research Team of the Mother-Child Couple, Faculty of Medicine, Mohammed 5th University, Rabat, Morocco.
  • Aguenaou H; CNESTEN, Joint Research Unit in Nutrition and Food, Regional Designated Center of Nutrition (AFRA/IAEA), Ibn Tofaïl University, Kenitra, Morocco.
Front Physiol ; 11: 595005, 2020.
Article in English | MEDLINE | ID: covidwho-970863
ABSTRACT

BACKGROUND:

The epidemic of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), presents a significant and urgent threat to global health. This alarming viral infection, declared as pandemic by the WHO in February 2020, has resulted millions of infected patients and thousands of deaths around the world. In Morocco, despite the efforts made by the authorities, the SARS-CoV-2 continues to spread and constitutes a burden of morbidity and mortality. The objective of this study is to describe clinical characteristics of COVID-19 Moroccan patients and to establish the relationship between specific clinical symptoms, namely ageusia and/or anosmia, with these characteristics.

METHODS:

We performed a descriptive, non-interventional cross-sectional study analyzing data from 108 patients admitted to the VINCI clinic, Casablanca (Morocco). The database includes 39 parameters including epidemiological characteristics, anthropometric measurements and biological analyzes.

RESULTS:

The average of age of the patients was 43.80 ± 15.75 years with a sex ratio of 11. The mean body mass index of the patients was 25.54 ± 4.63 Kg/m2. The majority of patients had, at least, one comorbidity and among 75% symptomatic patients, about 50% had, at least, three symptoms namely, fever (40.7%), cough (39.8%), myalgia (28.7%), and anosmia and/or ageusia (20.4%). From biological analyzes, we noticed lymphopenia and an elevated protein C reactive and lactate dehydrogenases levels in 24.1, 36.1, and 35.2% of patients, respectively. A disturbance in liver function markers was observed in 15.7% of cases. For the other hemostasis parameters, high levels of prothrombin and platelets were reported in 14.6 and 14.8% of patients, respectively. Comparisons related to the presence of anosmia and/or ageusia did not show any difference for demographic and anthropometric characteristics, while a possibility of a significant difference was revealed for certain biological parameters, particularly the levels of lymphocytes, D-dimer and troponin.

CONCLUSION:

This study provides significant findings that will be used not only to supplement previous studies carried out in Morocco in order to resume the epidemiological situation in comparison with other countries, but also to improve the quality of the diagnosis of COVID-19 patients by identifying all the symptoms of the disease and better understanding its clinical outcomes.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Front Physiol Year: 2020 Document Type: Article Affiliation country: Fphys.2020.595005

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Front Physiol Year: 2020 Document Type: Article Affiliation country: Fphys.2020.595005