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Sedentary behavior, exercise and COVID-19: immune and metabolic implications in obesity and its comorbidities.
Methnani, Jabeur; Amor, Dorra; Yousfi, Nariman; Bouslama, Ali; Omezzine, Asma; Bouhlel, Ezdine.
  • Methnani J; University of Manouba, High Institute of Sport and Physical Education, Ksar Said, Tunis, Tunisia - jabeur.methnani@gmail.com.
  • Amor D; Department of Biochemistry, LR12SP11, Sahloul University Hospital, Sousse, Tunisia - jabeur.methnani@gmail.com.
  • Yousfi N; Laboratory of Exercise Physiology and Physiopathology: from Integrated to Molecular Biology, Medicine and Health, LR19ES09, Faculty of Medicine of Sousse, Sousse, Tunisia - jabeur.methnani@gmail.com.
  • Bouslama A; Department of Biochemistry, LR12SP11, Sahloul University Hospital, Sousse, Tunisia.
  • Omezzine A; University of Monastir, Faculty of Pharmacy of Monastir, Monastir, Tunisia.
  • Bouhlel E; University of Manouba, High Institute of Sport and Physical Education, Ksar Said, Tunis, Tunisia.
J Sports Med Phys Fitness ; 61(11): 1538-1547, 2021 Nov.
Article in English | MEDLINE | ID: covidwho-970965
ABSTRACT
Many reports showed a dramatic decrease in the levels of physical activity during the current pandemic of SARS-CoV-2. This has substantial immune and metabolic implications, especially in those at risk or with metabolic diseases including individuals with obesity and Type 2 diabetes. In this study we discussed the route from physical inactivity to immune and metabolic aberrancies; focusing on how insulin resistance could represent an adaptive mechanism to the low physical activity levels and on how such an adaptive mechanism could shift to a pathognomonic feature of metabolic diseases, creating a vicious circle of immune and metabolic aberrancies. We provide a theoretical framework to the severe immunopathology of COVID-19 in patients with metabolic diseases. We finally discuss the idea of exercise as a potential adjuvant against COVID-19 and emphasize how even interrupting prolonged periods of sitting with short time breaks of very light activity could be a feasible strategy to limit the deleterious effects of the outbreak.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: J Sports Med Phys Fitness Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: J Sports Med Phys Fitness Year: 2021 Document Type: Article