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SARS-COV-2 Serological Profile in Healthcare Professionals of a Southern Italy Hospital.
De Carlo, Armando; Lo Caputo, Sergio; Paolillo, Carmela; Rosa, Anna Maria; D'Orsi, Umberto; De Palma, Maria; Reveglia, Pierluigi; Lacedonia, Donato; Cinnella, Gilda; Foschino, Maria Pia; Margaglione, Maurizio; Mirabella, Lucia; Santantonio, Teresa Antonia; Corso, Gaetano; Dattoli, Vitangelo.
  • De Carlo A; Azienda Ospedaliera-Universitaria Policlinico Riuniti di Foggia, 71122 Foggia, Italy.
  • Lo Caputo S; Azienda Ospedaliera-Universitaria Policlinico Riuniti di Foggia, 71122 Foggia, Italy.
  • Paolillo C; Dipartimento di Medicina Clinica e Sperimentale, Università di Foggia, 71122 Foggia, Italy.
  • Rosa AM; Dipartimento di Medicina Clinica e Sperimentale, Università di Foggia, 71122 Foggia, Italy.
  • D'Orsi U; Azienda Ospedaliera-Universitaria Policlinico Riuniti di Foggia, 71122 Foggia, Italy.
  • De Palma M; Azienda Ospedaliera-Universitaria Policlinico Riuniti di Foggia, 71122 Foggia, Italy.
  • Reveglia P; Azienda Ospedaliera-Universitaria Policlinico Riuniti di Foggia, 71122 Foggia, Italy.
  • Lacedonia D; Dipartimento di Medicina Clinica e Sperimentale, Università di Foggia, 71122 Foggia, Italy.
  • Cinnella G; Azienda Ospedaliera-Universitaria Policlinico Riuniti di Foggia, 71122 Foggia, Italy.
  • Foschino MP; Dipartimento di Scienze Mediche e Chirurgiche, Università di Foggia, 71122 Foggia, Italy.
  • Margaglione M; Azienda Ospedaliera-Universitaria Policlinico Riuniti di Foggia, 71122 Foggia, Italy.
  • Mirabella L; Dipartimento di Scienze Mediche e Chirurgiche, Università di Foggia, 71122 Foggia, Italy.
  • Santantonio TA; Azienda Ospedaliera-Universitaria Policlinico Riuniti di Foggia, 71122 Foggia, Italy.
  • Corso G; Dipartimento di Scienze Mediche e Chirurgiche, Università di Foggia, 71122 Foggia, Italy.
  • Dattoli V; Azienda Ospedaliera-Universitaria Policlinico Riuniti di Foggia, 71122 Foggia, Italy.
Int J Environ Res Public Health ; 17(24)2020 12 13.
Article in English | MEDLINE | ID: covidwho-970982
Semantic information from SemMedBD (by NLM)
1. Antibodies PART_OF 2019 novel coronavirus
Subject
Antibodies
Predicate
PART_OF
Object
2019 novel coronavirus
2. Responsive Disease COEXISTS_WITH Asymptomatic Infections
Subject
Responsive Disease
Predicate
COEXISTS_WITH
Object
Asymptomatic Infections
3. Antibodies PART_OF 2019 novel coronavirus
Subject
Antibodies
Predicate
PART_OF
Object
2019 novel coronavirus
4. Responsive Disease COEXISTS_WITH Asymptomatic Infections
Subject
Responsive Disease
Predicate
COEXISTS_WITH
Object
Asymptomatic Infections
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the first coronavirus that has caused a pandemic. Assessing the prevalence of anti-SARS-CoV-2 in healthcare worker groups offers a unique opportunity to study the correlation between seroconversion and immunization because of their occupational exposure and a higher risk of contagion. The study enrolled 3242 asymptomatic employees of "Policlinico Riuniti", Foggia. After the first screening, we collected sequential serum samples for up to 23 weeks from the same subjects. In order to perform a longitudinal follow-up study and get information about the titration of IgG levels, we analyzed data from subjects (33) with at least two consecutive serological IgG-positive tests; 62 (1.9%; 95% CI 1.4-2.3) tested positive for at least one anti-SARS-CoV-2 antibody. The seroprevalence was lower in the high-risk group 1.4% (6/428; 95% CI 0.5-2.6) vs. the intermediate-risk group 2.0% (55/2736; 95% CI 1.5-2.5). Overall, within eight weeks, we detected a mean reduction of -17% in IgG levels. Our data suggest a reduction of about 9.27 AU/mL every week (R2 = 0.35, p = 0.0003). This study revealed the prevalence of SARS-CoV-2 antibodies among Foggia's hospital healthcare staff (1.9%). Moreover, the IgG level reduction suggests that the serological response fades fast in asymptomatic infections.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Seroepidemiologic Studies / Health Personnel / COVID-19 / Antibodies, Viral Type of study: Observational study / Prognostic study / Randomized controlled trials / Risk factors Limits: Adult / Humans / Middle aged Country/Region as subject: Europa Language: English Year: 2020 Document Type: Article Affiliation country: Ijerph17249324

Full text: Available Collection: International databases Database: MEDLINE Main subject: Seroepidemiologic Studies / Health Personnel / COVID-19 / Antibodies, Viral Type of study: Observational study / Prognostic study / Randomized controlled trials / Risk factors Limits: Adult / Humans / Middle aged Country/Region as subject: Europa Language: English Year: 2020 Document Type: Article Affiliation country: Ijerph17249324