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The role of extracellular DNA in COVID-19: Clues from inflamm-aging.
Storci, Gianluca; Bonifazi, Francesca; Garagnani, Paolo; Olivieri, Fabiola; Bonafè, Massimiliano.
  • Storci G; Department of Experimental and Diagnostic Medicine, University of Bologna, Italy. Electronic address: gianluca.storci@unibo.it.
  • Bonifazi F; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Garagnani P; Department of Experimental and Diagnostic Medicine, University of Bologna, Italy; Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sweden.
  • Olivieri F; Department of Clinical and Molecular Sciences (DISCLIMO), Università Politecnica delle Marche, Ancona, Italy; Center of Clinical Pathology and Regenerative Therapy, IRCCS INRCA, Ancona, Italy.
  • Bonafè M; Department of Experimental and Diagnostic Medicine, University of Bologna, Italy. Electronic address: massimiliano.bonafe@unibo.it.
Ageing Res Rev ; 66: 101234, 2021 03.
Article in English | MEDLINE | ID: covidwho-971018
ABSTRACT
Epidemiological data convey severe prognosis and high mortality rate for COVID-19 in elderly men affected by age-related diseases. These subjects develop local and systemic hyper-inflammation, which are associated with thrombotic complications and multi-organ failure. Therefore, understanding SARS-CoV-2 induced hyper-inflammation in elderly men is a pressing need. Here we focus on the role of extracellular DNA, mainly mitochondrial DNA (mtDNA) and telomeric DNA (telDNA) in the modulation of systemic inflammation in these subjects. In particular, extracellular mtDNA is regarded as a powerful trigger of the inflammatory response. On the contrary, extracellular telDNA pool is estimated to be capable of inhibiting a variety of inflammatory pathways. In turn, we underpin that telDNA reservoir is progressively depleted during aging, and that it is scarcer in men than in women. We propose that an increase in extracellular mtDNA, concomitant with the reduction of the anti-inflammatory telDNA reservoir may explain hyper-inflammation in elderly male affected by COVID-19. This scenario is reminiscent of inflamm-aging, the portmanteau word that depicts how aging and aging related diseases are intimately linked to inflammation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Limits: Aged / Female / Humans / Male Language: English Journal: Ageing Res Rev Journal subject: Geriatrics Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Limits: Aged / Female / Humans / Male Language: English Journal: Ageing Res Rev Journal subject: Geriatrics Year: 2021 Document Type: Article