Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection.
PLoS One
; 15(12): e0243882, 2020.
Article
in English
| MEDLINE | ID: covidwho-971318
ABSTRACT
BACKGROUND:
Characterizing the prevalence and persistence of symptoms associated with COVID-19 infection following hospitalization and their impact is essential to planning post-acute community-based clinical services. This study seeks to identify persistent COVID-19 symptoms in patients 35 days post-hospitalization and their impact on quality of life, health, physical, mental, and psychosocial function. METHODS ANDFINDINGS:
This prospective cohort study used the PROMIS® Instruments to identify symptoms and quality of life parameters in consecutively enrolled patients between March 22 and April 16, 2020, in New Jersey. The 183 patients (median age 57 years; 61.5% male, 54.1% white) reported persistent symptoms at 35 days, including fatigue (55.0%), dyspnea (45.3%), muscular pain (51%), associated with a lower odds rating general health (41.5%, OR 0.093 [95% CI 0.026, 0.329], p = 0.0002), quality of life (39.8%; OR 0.116 [95% CI 0.038, 0.364], p = 0.0002), physical health (38.7%, OR 0.055 [95% CI 0.016, 0.193], p <0.0001), mental health (43.7%, OR 0.093 [95% CI 0.021, 0.418], p = 0.0019) and social active role (38.7%, OR 0.095 [95% CI 0.031, 0.291], p<0.0001), as very good/excellent, particularly adults aged 65 to 75 years (OR 8·666 [95% CI 2·216, 33·884], p = 0·0019).CONCLUSIONS:
COVID-19 symptoms commonly persist to 35 days, impacting quality of life, health, physical and mental function. Early post-acute evaluation of symptoms and their impact on function is necessary to plan community-based services.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Quality of Life
/
Mental Health
/
SARS-CoV-2
/
COVID-19
/
Hospitalization
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Qualitative research
Topics:
Long Covid
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
North America
Language:
English
Journal:
PLoS One
Journal subject:
Science
/
Medicine
Year:
2020
Document Type:
Article
Affiliation country:
Journal.pone.0243882
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