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mTOR inhibition in COVID-19: A commentary and review of efficacy in RNA viruses.
Karam, Basil S; Morris, Rachel S; Bramante, Carolyn T; Puskarich, Michael; Zolfaghari, Emily J; Lotfi-Emran, Sahar; Ingraham, Nicholas E; Charles, Anthony; Odde, David J; Tignanelli, Christopher J.
  • Karam BS; Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Morris RS; Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Bramante CT; Division of General Internal Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
  • Puskarich M; Department of Emergency Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
  • Zolfaghari EJ; University of Minnesota Medical School, Minneapolis, Minnesota, USA.
  • Lotfi-Emran S; Division of Rheumatology, Department of Medicine, Minneapolis, Minnesota, USA.
  • Ingraham NE; Division of Pulmonary and Critical Care, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
  • Charles A; Department of Surgery, University of North Carolina, Chapel Hill, North Carolina, USA.
  • Odde DJ; School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
  • Tignanelli CJ; Department of Biomedical Engineering, University of Minnesota, Minnesota, USA.
J Med Virol ; 93(4): 1843-1846, 2021 04.
Article in English | MEDLINE | ID: covidwho-971501
ABSTRACT
In this commentary, we shed light on the role of the mammalian target of rapamycin (mTOR) pathway in viral infections. The mTOR pathway has been demonstrated to be modulated in numerous RNA viruses. Frequently, inhibiting mTOR results in suppression of virus growth and replication. Recent evidence points towards modulation of mTOR in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We discuss the current literature on mTOR in SARS-CoV-2 and highlight evidence in support of a role for mTOR inhibitors in the treatment of coronavirus disease 2019.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA Viruses / TOR Serine-Threonine Kinases / SARS-CoV-2 / COVID-19 Drug Treatment Limits: Animals / Humans Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.26728

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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA Viruses / TOR Serine-Threonine Kinases / SARS-CoV-2 / COVID-19 Drug Treatment Limits: Animals / Humans Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.26728