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IgA2 Antibodies against SARS-CoV-2 Correlate with NET Formation and Fatal Outcome in Severely Diseased COVID-19 Patients.
Staats, Léonie A N; Pfeiffer, Hella; Knopf, Jasmin; Lindemann, Aylin; Fürst, Julia; Kremer, Andreas E; Hackstein, Holger; Neurath, Markus F; Muñoz, Luis E; Achenbach, Susanne; Leppkes, Moritz; Herrmann, Martin; Schett, Georg; Steffen, Ulrike.
  • Staats LAN; Department of Internal Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  • Pfeiffer H; Deutsches Zentrum Immuntherapie (DZI), 91054 Erlangen, Germany.
  • Knopf J; Department of Transfusion Medicine and Haemostaseology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  • Lindemann A; Deutsches Zentrum Immuntherapie (DZI), 91054 Erlangen, Germany.
  • Fürst J; Department of Internal Medicine 3, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  • Kremer AE; Department of Internal Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  • Hackstein H; Deutsches Zentrum Immuntherapie (DZI), 91054 Erlangen, Germany.
  • Neurath MF; Department of Internal Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  • Muñoz LE; Deutsches Zentrum Immuntherapie (DZI), 91054 Erlangen, Germany.
  • Achenbach S; Department of Internal Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  • Leppkes M; Deutsches Zentrum Immuntherapie (DZI), 91054 Erlangen, Germany.
  • Herrmann M; Department of Transfusion Medicine and Haemostaseology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  • Schett G; Department of Internal Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
  • Steffen U; Deutsches Zentrum Immuntherapie (DZI), 91054 Erlangen, Germany.
Cells ; 9(12)2020 12 12.
Article in English | MEDLINE | ID: covidwho-971834
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Neutrophil Extracellular Traps LOCATION_OF 2019 novel coronavirus
Subject
Neutrophil Extracellular Traps
Predicate
LOCATION_OF
Object
2019 novel coronavirus
3. Fatal Outcome PROCESS_OF Patients
Subject
Fatal Outcome
Predicate
PROCESS_OF
Object
Patients
4. IgA2 STIMULATES Immune Cell
Subject
IgA2
Predicate
STIMULATES
Object
Immune Cell
5. Specific antibody measurement USES spike protei
Subject
Specific antibody measurement
Predicate
USES
Object
spike protei
6. Specific antibody measurement MEASURES Plasma specimen
Subject
Specific antibody measurement
Predicate
MEASURES
Object
Plasma specimen
7. Cell-Free DNA PART_OF Extracellular
Subject
Cell-Free DNA
Predicate
PART_OF
Object
Extracellular
8. C-reactive protein PREDISPOSES Inflammation
Subject
C-reactive protein
Predicate
PREDISPOSES
Object
Inflammation
9. Cell-Free DNA PREDISPOSES Inflammation
Subject
Cell-Free DNA
Predicate
PREDISPOSES
Object
Inflammation
10. C-reactive protein compared_with Cell-Free DNA
Subject
C-reactive protein
Predicate
compared_with
Object
Cell-Free DNA
11. DNA PART_OF Extracellular
Subject
DNA
Predicate
PART_OF
Object
Extracellular
12. Patients LOCATION_OF IgA2
Subject
Patients
Predicate
LOCATION_OF
Object
IgA2
13. Patients LOCATION_OF SARS-CoV-2 IgG
Subject
Patients
Predicate
LOCATION_OF
Object
SARS-CoV-2 IgG
14. COVID-19 PREDISPOSES Severe disease
Subject
COVID-19
Predicate
PREDISPOSES
Object
Severe disease
15. IgA2 AFFECTS Neutrophil Extracellular Traps
Subject
IgA2
Predicate
AFFECTS
Object
Neutrophil Extracellular Traps
16. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
17. Neutrophil Extracellular Traps LOCATION_OF 2019 novel coronavirus
Subject
Neutrophil Extracellular Traps
Predicate
LOCATION_OF
Object
2019 novel coronavirus
18. Fatal Outcome PROCESS_OF Patients
Subject
Fatal Outcome
Predicate
PROCESS_OF
Object
Patients
19. IgA2 STIMULATES Immune Cell
Subject
IgA2
Predicate
STIMULATES
Object
Immune Cell
20. Specific antibody measurement USES spike protein, SARS-CoV-2
Subject
Specific antibody measurement
Predicate
USES
Object
spike protein, SARS-CoV-2
21. Specific antibody measurement MEASURES Plasma specimen
Subject
Specific antibody measurement
Predicate
MEASURES
Object
Plasma specimen
22. Cell-Free DNA PART_OF Extracellular
Subject
Cell-Free DNA
Predicate
PART_OF
Object
Extracellular
23. C-reactive protein PREDISPOSES Inflammation
Subject
C-reactive protein
Predicate
PREDISPOSES
Object
Inflammation
24. Cell-Free DNA PREDISPOSES Inflammation
Subject
Cell-Free DNA
Predicate
PREDISPOSES
Object
Inflammation
25. C-reactive protein compared_with Cell-Free DNA
Subject
C-reactive protein
Predicate
compared_with
Object
Cell-Free DNA
26. DNA PART_OF Extracellular
Subject
DNA
Predicate
PART_OF
Object
Extracellular
27. Patients LOCATION_OF IgA2
Subject
Patients
Predicate
LOCATION_OF
Object
IgA2
28. Patients LOCATION_OF SARS-CoV-2 IgG
Subject
Patients
Predicate
LOCATION_OF
Object
SARS-CoV-2 IgG
29. COVID-19 PREDISPOSES Severe disease
Subject
COVID-19
Predicate
PREDISPOSES
Object
Severe disease
30. IgA2 AFFECTS Neutrophil Extracellular Traps
Subject
IgA2
Predicate
AFFECTS
Object
Neutrophil Extracellular Traps
ABSTRACT
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to an adaptive immune response in the host and the formation of anti-SARS-CoV-2 specific antibodies. While IgG responses against SARS-CoV-2 have been characterized quite well, less is known about IgA. IgA2 activates immune cells and induces inflammation and neutrophil extracellular trap (NET) formation which may contribute to organ injury and fatal outcome in SARS-CoV-2-infected patients. SARS-CoV-2 spike protein specific antibody levels were measured in plasma samples of 15 noninfected controls and 82 SARS-CoV-2-infected patients with no or mild symptoms, moderate symptoms (hospitalization) or severe disease (intensive care unit, ICU). Antibody levels were compared to levels of C-reactive protein (CRP) and circulating extracellular DNA (ecDNA) as markers for general inflammation and NET formation, respectively. While levels of SARS-CoV-2-specific IgG were similar in all patient groups, IgA2 antibodies were restricted to severe disease and showed the strongest discrimination between nonfatal and fatal outcome in patients with severe SARS-CoV-2 infection. While anti-SARS-CoV-2 IgG and IgA2 levels correlated with CRP levels in severely diseased patients, only anti-SARS-CoV-2 IgA2 correlated with ecDNA. These data suggest that the formation of anti-SARS-CoV-2 IgA2 during SARS-CoV-2 infection is a marker for more severe disease related to NET formation and poor outcome.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Immunoglobulin A / Spike Glycoprotein, Coronavirus / Extracellular Traps / COVID-19 / Antibodies, Viral Subject: Immunoglobulin A / Spike Glycoprotein, Coronavirus / Extracellular Traps / COVID-19 / Antibodies, Viral Type of study: Observational study Language: English Year: 2020

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Immunoglobulin A / Spike Glycoprotein, Coronavirus / Extracellular Traps / COVID-19 / Antibodies, Viral Subject: Immunoglobulin A / Spike Glycoprotein, Coronavirus / Extracellular Traps / COVID-19 / Antibodies, Viral Type of study: Observational study Language: English Year: 2020
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