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Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vaginal swabs of women with acute SARS-CoV-2 infection: a prospective study.
Schwartz, A; Yogev, Y; Zilberman, A; Alpern, S; Many, A; Yousovich, R; Gamzu, R.
  • Schwartz A; Department of Obstetrics and Gynaecology, Lis Maternity Hospital, Sourasky Medical Centre, Tel Aviv, Israel.
  • Yogev Y; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Zilberman A; Department of Obstetrics and Gynaecology, Lis Maternity Hospital, Sourasky Medical Centre, Tel Aviv, Israel.
  • Alpern S; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Many A; Department of Obstetrics and Gynaecology, Lis Maternity Hospital, Sourasky Medical Centre, Tel Aviv, Israel.
  • Yousovich R; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Gamzu R; Department of Obstetrics and Gynaecology, Lis Maternity Hospital, Sourasky Medical Centre, Tel Aviv, Israel.
BJOG ; 128(1): 97-100, 2021 01.
Article in English | MEDLINE | ID: covidwho-972231
Semantic information from SemMedBD (by NLM)
1. Acute infectious disease PROCESS_OF Woman
Subject
Acute infectious disease
Predicate
PROCESS_OF
Object
Woman
2. Postmenopausal state PROCESS_OF Woman
Subject
Postmenopausal state
Predicate
PROCESS_OF
Object
Woman
3. Present COEXISTS_WITH Acute infectious disease
Subject
Present
Predicate
COEXISTS_WITH
Object
Acute infectious disease
4. Mild disorder PROCESS_OF Woman
Subject
Mild disorder
Predicate
PROCESS_OF
Object
Woman
5. Vagina LOCATION_OF Colonization
Subject
Vagina
Predicate
LOCATION_OF
Object
Colonization
6. Acute infectious disease PROCESS_OF Woman
Subject
Acute infectious disease
Predicate
PROCESS_OF
Object
Woman
7. Postmenopausal state PROCESS_OF Woman
Subject
Postmenopausal state
Predicate
PROCESS_OF
Object
Woman
8. Present COEXISTS_WITH Acute infectious disease
Subject
Present
Predicate
COEXISTS_WITH
Object
Acute infectious disease
9. Mild disorder PROCESS_OF Woman
Subject
Mild disorder
Predicate
PROCESS_OF
Object
Woman
10. Vagina LOCATION_OF Colonization
Subject
Vagina
Predicate
LOCATION_OF
Object
Colonization
ABSTRACT

OBJECTIVE:

To determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is present in the vaginal secretions of both reproductive-aged and postmenopausal women during acute SARS-CoV-2 infection.

DESIGN:

Prospective study.

SETTING:

A single tertiary, university-affiliated medical centre in Israel. Time period, 1 June 2020 through to 31 July 2020. POPULATION Women who were hospitalised in a single tertiary medical centre, who were diagnosed with acute SARS-CoV-2 infection by a nasopharyngeal RT-PCR test.

METHODS:

Women were diagnosed with acute SARS-CoV-2 infection by a nasopharyngeal RT-PCR test. Vaginal RT-PCR swabs were obtained from all study participants after a proper cleansing of the perineum. MAIN OUTCOME

MEASURES:

Detection of SARS-CoV-2 in vaginal RT-PCR swabs.

RESULTS:

Vaginal and nasopharyngeal swabs were obtained from 35 women, aged 21-93 years. Twenty-one women (60%) were in their reproductive years, of whom, five were in their third trimester of pregnancy. Most of the participants (57%) were healthy without any underlying medical conditions. Of the 35 patients sampled, 2 (5.7%) had a positive vaginal RT-PCR for SARS-CoV-2, one was premenopausal and the other was a postmenopausal woman. Both women had mild disease.

CONCLUSION:

Our findings contradict most previous reports, which did not detect the presence of viral colonisation in the vagina. Although passage through the birth canal exposes neonates to the vaginal polymicrobial flora, an acquisition of pathogens does not necessarily mandate neonatal infection or clinical disease. Nevertheless, when delivering the infant of a woman with acute SARS-CoV-2 infection, a clinician should consider the possibility of vaginal colonisation, even if it is uncommon. TWEETABLE ABSTRACT When delivering the infant of a woman with acute SARS-CoV-2 infection, a clinician should consider the possibility of vaginal colonisation.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Pregnancy Complications, Infectious / Vagina / SARS-CoV-2 / COVID-19 Subject: Pregnancy Complications, Infectious / Vagina / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Risk factors Language: English Journal: BJOG Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Pregnancy Complications, Infectious / Vagina / SARS-CoV-2 / COVID-19 Subject: Pregnancy Complications, Infectious / Vagina / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Risk factors Language: English Journal: BJOG Year: 2021
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