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Cytokine Storms in Cancer and COVID-19.
Turnquist, Casmir; Ryan, Bríd M; Horikawa, Izumi; Harris, Brent T; Harris, Curtis C.
  • Turnquist C; University of Oxford Medical School, John Radcliffe Hospital, Oxford, UK; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
  • Ryan BM; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
  • Horikawa I; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
  • Harris BT; Departments of Neurology and Pathology, Georgetown University Medical Center, Washington, DC 20007, USA.
  • Harris CC; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. Electronic address: curtis_harris@nih.gov.
Cancer Cell ; 38(5): 598-601, 2020 11 09.
Article in English | MEDLINE | ID: covidwho-972270
ABSTRACT
During the COVID-19 pandemic, research on "cytokine storms" has been reinvigorated in the field of infectious disease, but it also has particular relevance to cancer research. Interleukin-6 (IL-6) has emerged as a key component of the immune response to SARS-CoV-2, such that the repurposing of anti-IL-6 therapeutics for COVID-19 is now a major line of investigation, with several ongoing clinical trials. We lay a framework for understanding the role of IL-6 in the context of cancer research and COVID-19 and suggest how lessons learned from cancer research may impact SARS-CoV-2 research and vice versa.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Severity of Illness Index / Cytokines / Coronavirus Infections / Betacoronavirus / Inflammation / Neoplasms Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Cancer Cell Journal subject: Neoplasms Year: 2020 Document Type: Article Affiliation country: J.ccell.2020.09.019

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Severity of Illness Index / Cytokines / Coronavirus Infections / Betacoronavirus / Inflammation / Neoplasms Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Cancer Cell Journal subject: Neoplasms Year: 2020 Document Type: Article Affiliation country: J.ccell.2020.09.019