Cytokine Storms in Cancer and COVID-19.
Cancer Cell
; 38(5): 598-601, 2020 11 09.
Article
in English
| MEDLINE | ID: covidwho-972270
ABSTRACT
During the COVID-19 pandemic, research on "cytokine storms" has been reinvigorated in the field of infectious disease, but it also has particular relevance to cancer research. Interleukin-6 (IL-6) has emerged as a key component of the immune response to SARS-CoV-2, such that the repurposing of anti-IL-6 therapeutics for COVID-19 is now a major line of investigation, with several ongoing clinical trials. We lay a framework for understanding the role of IL-6 in the context of cancer research and COVID-19 and suggest how lessons learned from cancer research may impact SARS-CoV-2 research and vice versa.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Severity of Illness Index
/
Cytokines
/
Coronavirus Infections
/
Betacoronavirus
/
Inflammation
/
Neoplasms
Type of study:
Prognostic study
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Cancer Cell
Journal subject:
Neoplasms
Year:
2020
Document Type:
Article
Affiliation country:
J.ccell.2020.09.019
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