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Complement Factors in COVID-19 Therapeutics and Vaccines.
Kurtovic, Liriye; Beeson, James G.
  • Kurtovic L; Burnet Institute, Melbourne, Australia; Department of Immunology and Pathology, Monash University, Melbourne, Australia.
  • Beeson JG; Burnet Institute, Melbourne, Australia; Department of Immunology and Pathology, Monash University, Melbourne, Australia; Central Clinical School and Department of Microbiology, Monash University, Melbourne, Australia; Department of Medicine, The University of Melbourne, Parkville, Australia. Electronic address: beeson@burnet.edu.au.
Trends Immunol ; 42(2): 94-103, 2021 02.
Article in English | MEDLINE | ID: covidwho-972553
ABSTRACT
Complement is integral to a healthy functioning immune system and orchestrates various innate and adaptive responses against viruses and other pathogens. Despite its importance, the potential beneficial role of complement in immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been overshadowed by reports of extensive complement activation in severe coronavirus disease 2019 (COVID-19) patients. Here, we hypothesize that complement may also have a protective role and could function to enhance virus neutralization by antibodies, promote virus phagocytosis by immune cells, and lysis of virus. These functions might be exploited in the development of effective therapeutics and vaccines against SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Topics: Vaccines Limits: Animals / Humans Language: English Journal: Trends Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: J.it.2020.12.002

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Topics: Vaccines Limits: Animals / Humans Language: English Journal: Trends Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: J.it.2020.12.002