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Case Report: Convalescent Plasma, a Targeted Therapy for Patients with CVID and Severe COVID-19.
Van Damme, Karel F A; Tavernier, Simon; Van Roy, Nele; De Leeuw, Elisabeth; Declercq, Jozefien; Bosteels, Cédric; Maes, Bastiaan; De Bruyne, Marieke; Bogaert, Delfien; Bosteels, Victor; Hoste, Levi; Naesens, Leslie; Maes, Piet; Grifoni, Alba; Weiskopf, Daniela; Sette, Alessandro; Depuydt, Pieter; Van Braeckel, Eva; Haerynck, Filomeen; Lambrecht, Bart N.
  • Van Damme KFA; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
  • Tavernier S; Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
  • Van Roy N; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
  • De Leeuw E; Unit of Molecular Signal Transduction in Inflammation, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
  • Declercq J; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
  • Bosteels C; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
  • Maes B; Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
  • De Bruyne M; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
  • Bogaert D; Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
  • Bosteels V; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
  • Hoste L; Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
  • Naesens L; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
  • Maes P; Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
  • Grifoni A; Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.
  • Weiskopf D; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
  • Sette A; Primary Immunodeficiency Research Lab, Jeffrey Modell Diagnosis and Research Center, Ghent University Hospital, Ghent, Belgium.
  • Depuydt P; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
  • Van Braeckel E; Laboratory of ER Stress and Inflammation, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
  • Haerynck F; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
  • Lambrecht BN; Primary Immunodeficiency Research Lab, Jeffrey Modell Diagnosis and Research Center, Ghent University Hospital, Ghent, Belgium.
Front Immunol ; 11: 596761, 2020.
Article in English | MEDLINE | ID: covidwho-972668
ABSTRACT
The disease course of COVID-19 in patients with immunodeficiencies is unclear, as well as the optimal therapeutic strategy. We report a case of a 37-year old male with common variable immunodeficiency disorder and a severe SARS-CoV-2 infection. After administration of convalescent plasma, the patient's condition improved rapidly. Despite clinical recovery, viral RNA remained detectable up to 60 days after onset of symptoms. We propose that convalescent plasma might be considered as a treatment option in patients with CVID and severe COVID-19. In addition, in patients with immunodeficiencies, a different clinical course is possible, with prolonged viral shedding.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA, Viral / Virus Shedding / Common Variable Immunodeficiency / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Case report / Prognostic study Topics: Long Covid Limits: Adult / Humans / Male Language: English Journal: Front Immunol Year: 2020 Document Type: Article Affiliation country: Fimmu.2020.596761

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Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA, Viral / Virus Shedding / Common Variable Immunodeficiency / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Case report / Prognostic study Topics: Long Covid Limits: Adult / Humans / Male Language: English Journal: Front Immunol Year: 2020 Document Type: Article Affiliation country: Fimmu.2020.596761