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Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore.
Seneviratne, Chaminda J; Balan, Preethi; Ko, Kwan Ki Karrie; Udawatte, Nadeeka S; Lai, Deborah; Ng, Dorothy Hui Lin; Venkatachalam, Indumathi; Lim, Kheng Sit; Ling, Moi Lin; Oon, Lynette; Goh, Bee Tin; Sim, Xiang Ying Jean.
  • Seneviratne CJ; Singapore Oral Microbiomics Initiative, National Dental Research Institute Singapore (NDRIS), National Dental Centre Singapore, SingHealth, Singapore, Singapore. jaya.seneviratne@ndcs.com.sg.
  • Balan P; Duke NUS Medical School, Oral Health ACP, Singapore, Singapore. jaya.seneviratne@ndcs.com.sg.
  • Ko KKK; Singapore Oral Microbiomics Initiative, National Dental Research Institute Singapore (NDRIS), National Dental Centre Singapore, SingHealth, Singapore, Singapore.
  • Udawatte NS; Duke NUS Medical School, Oral Health ACP, Singapore, Singapore.
  • Lai D; Department of Microbiology, Singapore General Hospital, SingHealth, Singapore, Singapore.
  • Ng DHL; Singapore Oral Microbiomics Initiative, National Dental Research Institute Singapore (NDRIS), National Dental Centre Singapore, SingHealth, Singapore, Singapore.
  • Venkatachalam I; Department of Microbiology, Singapore General Hospital, SingHealth, Singapore, Singapore.
  • Lim KS; Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore.
  • Ling ML; Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore.
  • Oon L; Department of Urology, Singapore General Hospital, Singapore, Singapore.
  • Goh BT; Department of Infection Prevention and Epidemiology, Singapore General Hospital, Singapore, Singapore.
  • Sim XYJ; Department of Microbiology, Singapore General Hospital, SingHealth, Singapore, Singapore.
Infection ; 49(2): 305-311, 2021 Apr.
Article in English | MEDLINE | ID: covidwho-973708
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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ABSTRACT

PURPOSE:

One of the key approaches to minimize the risk of COVID-19 transmission would be to reduce the titres of SARS-CoV-2 in the saliva of infected COVID-19 patients. This is particularly important in high-risk procedures like dental treatment. The present randomized control trial evaluated the efficacy of three commercial mouth-rinse viz. povidone-iodine (PI), chlorhexidine gluconate (CHX) and cetylpyridinium chloride (CPC), in reducing the salivary SARS-CoV-2 viral load in COVID-19 patients compared with water.

METHODS:

A total of 36 SARS-CoV-2-positive patients were recruited, of which 16 patients were randomly assigned to four groups-PI group (n = 4), CHX group (n = 6), CPC group (n = 4) and water as control group (n = 2). Saliva samples were collected from all patients at baseline and at 5 min, 3 h and 6 h post-application of mouth-rinses/water. The samples were subjected to SARS-CoV-2 RT-PCR analysis.

RESULTS:

Comparison of salivary Ct values of patients within each group of PI, CHX, CPC and water at 5 min, 3 h and 6 h time points did not show any significant differences. However, when the Ct value fold change of each of the mouth-rinse group patients were compared with the fold change of water group patients at the respective time points, a significant increase was observed in the CPC group patients at 5 min and 6 h and in the PI group patients at 6 h.

CONCLUSION:

The effect of decreasing salivary load with CPC and PI mouth-rinsing was observed to be sustained at 6 h time point. Within the limitation of the current study, as number of the samples analyzed, the use of CPC and PI formulated that commercial mouth-rinses may be useful as a pre-procedural rinse to help reduce the transmission of COVID-19. ISRCTN (ISRCTN95933274), 09/09/20, retrospectively registered.
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Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Saliva / Viral Load / SARS-CoV-2 / COVID-19 Drug Treatment / Anti-Infective Agents, Local / Mouthwashes Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Infection Year: 2021 Document Type: Article Affiliation country: S15010-020-01563-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Saliva / Viral Load / SARS-CoV-2 / COVID-19 Drug Treatment / Anti-Infective Agents, Local / Mouthwashes Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Infection Year: 2021 Document Type: Article Affiliation country: S15010-020-01563-9