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COVID-19 pneumonia: CD8+ T and NK cells are decreased in number but compensatory increased in cytotoxic potential.
Jiang, Yujie; Wei, Xin; Guan, Jingjing; Qin, Shuang; Wang, Zhongyong; Lu, Hong; Qian, Jingjing; Wu, Lianfeng; Chen, Yingxiao; Chen, Yanfan; Lin, Xiangyang.
  • Jiang Y; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
  • Wei X; Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China.
  • Guan J; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
  • Qin S; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
  • Wang Z; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
  • Lu H; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
  • Qian J; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
  • Wu L; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
  • Chen Y; Department of Infectious Diseases, The First Affiliated Hospital of Wenzhou, Medical University, Wenzhou 325000, China.
  • Chen Y; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. Electronic address: chenyf2605@163.com.
  • Lin X; Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. Electronic address: linxy1968@126.com.
Clin Immunol ; 218: 108516, 2020 09.
Article in English | MEDLINE | ID: covidwho-973956
ABSTRACT

BACKGROUND:

Coronavirus disease 2019 (COVID-19) is posing a huge threat to human health worldwide. We aim to investigate the immune status of CD8+ T and NK cells in COVID-19 patients.

METHODS:

The count and immune status of lymphocytes were detected by flow cytometry in 32 COVID-19 patients and 18 healthy individuals.

RESULTS:

As the disease progression in COVID-19 patients, CD8+ T and NK cells were significantly decreased in absolute number but highly activated. After patients' condition improved, the count and immune status of CD8+ T and NK cells restored to some extent. GrA+CD8+ T and perforin+ NK cells had good sensitivity and specificity for assisting diagnosis of COVID-19.

CONCLUSIONS:

As the disease progression, the declined lymphocytes in COVID-19 patients might lead to compensatory activation of CD8+ T and NK cells. GrA+CD8+ T and perforin+ NK cells might be used as meaningful indicators for assisting diagnosis of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Killer Cells, Natural / T-Lymphocytes, Cytotoxic / Coronavirus Infections / Granzymes / Perforin / Betacoronavirus Type of study: Diagnostic study / Observational study / Prognostic study Country/Region as subject: Asia Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2020 Document Type: Article Affiliation country: J.clim.2020.108516

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Killer Cells, Natural / T-Lymphocytes, Cytotoxic / Coronavirus Infections / Granzymes / Perforin / Betacoronavirus Type of study: Diagnostic study / Observational study / Prognostic study Country/Region as subject: Asia Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2020 Document Type: Article Affiliation country: J.clim.2020.108516