COVID-19 pneumonia: CD8+ T and NK cells are decreased in number but compensatory increased in cytotoxic potential.
Clin Immunol
; 218: 108516, 2020 09.
Article
in English
| MEDLINE | ID: covidwho-973956
ABSTRACT
BACKGROUND:
Coronavirus disease 2019 (COVID-19) is posing a huge threat to human health worldwide. We aim to investigate the immune status of CD8+ T and NK cells in COVID-19 patients.METHODS:
The count and immune status of lymphocytes were detected by flow cytometry in 32 COVID-19 patients and 18 healthy individuals.RESULTS:
As the disease progression in COVID-19 patients, CD8+ T and NK cells were significantly decreased in absolute number but highly activated. After patients' condition improved, the count and immune status of CD8+ T and NK cells restored to some extent. GrA+CD8+ T and perforin+ NK cells had good sensitivity and specificity for assisting diagnosis of COVID-19.CONCLUSIONS:
As the disease progression, the declined lymphocytes in COVID-19 patients might lead to compensatory activation of CD8+ T and NK cells. GrA+CD8+ T and perforin+ NK cells might be used as meaningful indicators for assisting diagnosis of COVID-19.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Killer Cells, Natural
/
T-Lymphocytes, Cytotoxic
/
Coronavirus Infections
/
Granzymes
/
Perforin
/
Betacoronavirus
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Country/Region as subject:
Asia
Language:
English
Journal:
Clin Immunol
Journal subject:
Allergy and Immunology
Year:
2020
Document Type:
Article
Affiliation country:
J.clim.2020.108516
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