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Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan. A Retrospective Observational Study.
Du, Yingzhen; Tu, Lei; Zhu, Pingjun; Mu, Mi; Wang, Runsheng; Yang, Pengcheng; Wang, Xi; Hu, Chao; Ping, Rongyu; Hu, Peng; Li, Tianzhi; Cao, Feng; Chang, Christopher; Hu, Qinyong; Jin, Yang; Xu, Guogang.
  • Du Y; Department of Respiratory Medicine, the Second Medical Center & National Clinical Research Center for Geriatric Diseases, Medical School of Chinese People's Liberation Army (PLA).
  • Tu L; Division of Gastroenterology, Wuhan Union Hospital, Tongji Medical College and.
  • Zhu P; Department of Respiratory Medicine, the Second Medical Center & National Clinical Research Center for Geriatric Diseases, Medical School of Chinese People's Liberation Army (PLA).
  • Mu M; Department of Respiratory Medicine, the Second Medical Center & National Clinical Research Center for Geriatric Diseases, Medical School of Chinese People's Liberation Army (PLA).
  • Wang R; Department of Respiratory Medicine, the Second Medical Center & National Clinical Research Center for Geriatric Diseases, Medical School of Chinese People's Liberation Army (PLA).
  • Yang P; Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China.
  • Wang X; Wuhan Hannan Hospital, Wuhan, China.
  • Hu C; Department of Cardiology, the Second Medical Center & National Clinical Research Center for Geriatric Diseases, and.
  • Ping R; The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
  • Hu P; The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
  • Li T; The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
  • Cao F; The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
  • Chang C; The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
  • Hu Q; Division of Rheumatology, Allergy, and Clinical Immunology, University of California Davis, Davis, California; and.
  • Jin Y; Division of Pediatric Immunology and Allergy, Joe DiMaggio Children's Hospital, Hollywood, Florida.
  • Xu G; Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China.
Am J Respir Crit Care Med ; 201(11): 1372-1379, 2020 06 01.
Article in English | MEDLINE | ID: covidwho-975792
ABSTRACT
Rationale The global death toll from coronavirus disease (COVID-19) virus as of May 12, 2020, exceeds 286,000. The risk factors for death were attributed to advanced age and comorbidities but have not been accurately defined.

Objectives:

To report the clinical features of 85 fatal cases of COVID-19 in two hospitals in Wuhan.

Methods:

Medical records were collected of 85 fatal cases of COVID-19 between January 9, 2020, and February 15, 2020. Information recorded included medical history, exposure history, comorbidities, symptoms, signs, laboratory findings, computed tomographic scans, and clinical management.Measurements and Main

Results:

The median age of the patients was 65.8 years, and 72.9% were male. Common symptoms were fever (78 [91.8%]), shortness of breath (50 [58.8%]), fatigue (50 [58.8%]), and dyspnea (60 [70.6%]). Hypertension, diabetes, and coronary heart disease were the most common comorbidities. Notably, 81.2% of patients had very low eosinophil counts on admission. Complications included respiratory failure (80 [94.1%]), shock (69 [81.2%]), acute respiratory distress syndrome (63 [74.1%]), and arrhythmia (51 [60%]), among others. Most patients received antibiotic (77 [90.6%]), antiviral (78 [91.8%]), and glucocorticoid (65 [76.5%]) treatments. A total of 38 (44.7%) and 33 (38.8%) patients received intravenous immunoglobulin and IFN-α2b, respectively.

Conclusions:

In this depictive study of 85 fatal cases of COVID-19, most cases were males aged over 50 years with noncommunicable chronic diseases. The majority of the patients died of multiple organ failure. Early onset of shortness of breath may be used as an observational symptom for COVID-19 exacerbations. Eosinophilopenia may indicate a poor prognosis. A combination of antimicrobial drugs did not offer considerable benefit to the outcome of this group of patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections Type of study: Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Am J Respir Crit Care Med Journal subject: Critical Care Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections Type of study: Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Am J Respir Crit Care Med Journal subject: Critical Care Year: 2020 Document Type: Article