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The predictive and diagnostic accuracy of long pentraxin-3 in COVID-19 pneumonia
Genç, Ahmed Bilal; Yaylaci, Selçuk; Dheir, Hamad; Genç, Ahmed Cihad; Issever, Kubilay; Çekiç, Deniz; Kocayigit, Havva; Çokluk, Erdem; Karacan, Alper; Sekeroglu, Mehmet Ramazan; Toptan Çakar, Hande; Güçlü, Ertugrul.
  • Genç AB; Department of Internal Medicine, Faculty of Medicine, Sakarya University, Sakarya, Turkey
  • Yaylaci S; Department of Internal Medicine, Faculty of Medicine, Sakarya University, Sakarya, Turkey
  • Dheir H; Department of Internal Medicine, Faculty of Medicine, Sakarya University, Sakarya, Turkey
  • Genç AC; Department of Internal Medicine, Faculty of Medicine, Sakarya University, Sakarya, Turkey
  • Issever K; Department of Internal Medicine, Faculty of Medicine, Sakarya University, Sakarya, Turkey
  • Çekiç D; Department of Internal Medicine, Faculty of Medicine, Sakarya University, Sakarya, Turkey
  • Kocayigit H; Department of Intensive Care, Faculty of Medicine, Sakarya University, Sakarya, Turkey
  • Çokluk E; Department of Biochemistry, Faculty of Medicine, Sakarya University, Sakarya, Turkey
  • Karacan A; Department of Radiology, Faculty of Medicine, Sakarya University, Sakarya, Turkey
  • Sekeroglu MR; Department of Biochemistry, Faculty of Medicine, Sakarya University, Sakarya, Turkey
  • Toptan Çakar H; Department of Biochemistry, Faculty of Medicine, Sakarya University, Sakarya, Turkey
  • Güçlü E; Department of Microbiology, Faculty of Medicine, Sakarya University, Sakarya, Turkey
Turk J Med Sci ; 51(2): 448-453, 2021 04 30.
Article in English | MEDLINE | ID: covidwho-976380
ABSTRACT
Background/

aim:

The purpose of this study is to evaluate serum pentraxin-3 (PTX-3) levels in Sars-CoV-2 virus infection (COVID-19) patients and to investigate whether PTX-3 predicts the disease prognosis. Materials and

methods:

This study was conducted on 88 confirmed COVID-19 patients who were hospitalized due to symptomatic pneumonia between April 15 and August 15, 2020. The patients were divided into two groups as survived patients and non-survived patients. Both groups were compared according to demographic features, comorbid conditions and measurement of the PTX-3 and other laboratory parameters of the patients.

Results:

Of 88 patients with COVID-19, 59 (67%) were discharged with complete cure and 29 (33%) resulted in death. 46 (52.3%) of the patients were men. PTX-3 median value (IQR) was 3.66 ng/mL (0.9­27.9) in all patients, 3.3 ng/mL (0.9­27.9) in survivors and 3.91 ng/mL (1.9­23.2) in nonsurvivors which was significantly higher (P = 0.045). As a receiver operating characteristic curve analysis the cut-off value of PTX-3 for predicting mortality in patients was 3.73 with 65% sensitivity and 65% specificity (AUC 0.646, 95% CI 0.525­ 0.767, P = 0.045). Also, we found significant cut-off values with respect to D-dimer, D-dimer/PTX-3, high-sensitivity troponin, high- sensitivity troponin/PTX-3, lymphocyte, PTX-3/lymphocyte, procalcitonin, procalcitonin/PTX-3, CRP, and CRP/PTX-3 (P < 0.05).

Conclusion:

In this study, as far as we know, for the first time, we have shown PTX-3 as the new mortality biomarker for COVID-19 disease.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: C-Reactive Protein / Serum Amyloid P-Component / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Turk J Med Sci Year: 2021 Document Type: Article Affiliation country: Sag-2011-32

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Full text: Available Collection: International databases Database: MEDLINE Main subject: C-Reactive Protein / Serum Amyloid P-Component / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Turk J Med Sci Year: 2021 Document Type: Article Affiliation country: Sag-2011-32