The predictive and diagnostic accuracy of long pentraxin-3 in COVID-19 pneumonia
Turk J Med Sci
; 51(2): 448-453, 2021 04 30.
Article
in English
| MEDLINE | ID: covidwho-976380
ABSTRACT
Background/aim:
The purpose of this study is to evaluate serum pentraxin-3 (PTX-3) levels in Sars-CoV-2 virus infection (COVID-19) patients and to investigate whether PTX-3 predicts the disease prognosis. Materials andmethods:
This study was conducted on 88 confirmed COVID-19 patients who were hospitalized due to symptomatic pneumonia between April 15 and August 15, 2020. The patients were divided into two groups as survived patients and non-survived patients. Both groups were compared according to demographic features, comorbid conditions and measurement of the PTX-3 and other laboratory parameters of the patients.Results:
Of 88 patients with COVID-19, 59 (67%) were discharged with complete cure and 29 (33%) resulted in death. 46 (52.3%) of the patients were men. PTX-3 median value (IQR) was 3.66 ng/mL (0.927.9) in all patients, 3.3 ng/mL (0.927.9) in survivors and 3.91 ng/mL (1.923.2) in nonsurvivors which was significantly higher (P = 0.045). As a receiver operating characteristic curve analysis the cut-off value of PTX-3 for predicting mortality in patients was 3.73 with 65% sensitivity and 65% specificity (AUC 0.646, 95% CI 0.525 0.767, P = 0.045). Also, we found significant cut-off values with respect to D-dimer, D-dimer/PTX-3, high-sensitivity troponin, high- sensitivity troponin/PTX-3, lymphocyte, PTX-3/lymphocyte, procalcitonin, procalcitonin/PTX-3, CRP, and CRP/PTX-3 (P < 0.05).Conclusion:
In this study, as far as we know, for the first time, we have shown PTX-3 as the new mortality biomarker for COVID-19 disease.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
C-Reactive Protein
/
Serum Amyloid P-Component
/
COVID-19
Type of study:
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
Topics:
Long Covid
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
/
Young adult
Language:
English
Journal:
Turk J Med Sci
Year:
2021
Document Type:
Article
Affiliation country:
Sag-2011-32
Similar
MEDLINE
...
LILACS
LIS