Covid-19, heat shock proteins, and autoimmune bullous diseases: a potential link deserving further attention.
Cell Stress Chaperones
; 26(1): 1-2, 2021 01.
Article
in English
| MEDLINE | ID: covidwho-977006
ABSTRACT
A link between Covid-19 and development of autoimmunity has been reported. A possible explanation could be molecular mimicry between SARS-CoV-2 and human proteins. Peptide sharing has been found between antigenic epitopes of this virus and heat shock proteins (Hsp) 60 and 90, both of which are associated with autoimmune diseases including those of the bullous type. In particular, there is evidence for the latter Hsp acting as a pathophysiological factor and treatment target in autoimmune blistering dermatoses. Considering multimodal anti-inflammatory mechanisms of action of anti-Hsp90 treatment and drug repositioning results, it may be hypothesized that Hsp90 inhibition could also be a treatment option for cytokine storm-mediated acute respiratory distress syndrome in Covid-19 patients. Hence, although Covid-19-induced autoimmune bullous diseases have not been described in the literature so far, the potential relationship between Covid-19, Hsp, and these autoimmune disorders deserves further attention with respect to both pathophysiology and treatment.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Autoimmune Diseases
/
Guillain-Barre Syndrome
/
COVID-19
Limits:
Humans
Language:
English
Journal:
Cell Stress Chaperones
Year:
2021
Document Type:
Article
Affiliation country:
S12192-020-01180-3
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