Low-dose radiotherapy (LD-RT) for COVID-19-induced pneumopathy: a worth considering approach.
Int J Radiat Biol
; 97(3): 302-312, 2021.
Article
in English
| MEDLINE | ID: covidwho-977319
ABSTRACT
PURPOSE:
It seems that 2020 would be always remembered by the name of novel coronavirus (designated as SARS-CoV-2), which exerted its deteriorating effects on the health care, economy, education, and political relationships. In August 2020 more than eight hundred thousand patients lost their lives due to acute respiratory syndrome. In the limited list of therapeutic approaches, the effectiveness of low-dose radiation therapy (LD-RT) for curing inflammatory-related diseases have sparkled a light that probably this approach would bring promising advantages for COVID-19 patients. LD-RT owns its reputation from its ability to modulate the host inflammatory responses by blocking the production of pro-inflammatory cytokines and hampering the activity of leukocytes. Moreover, the cost-effective and availability of this method allow it to be applied to a large number of patients, especially those who could not receive anti-IL-6 treatments in low-income countries. But enthusiasm for applying LD-RT for the treatment of COVID-19 patients has been muted yet.CONCLUSION:
In this review, we take a look at LD-RT mechanisms of action in the treatment of nonmalignant diseases, and then through studying both the dark and bright sides of this approach, we provide a thorough discussion if LD-RT might be a promising therapeutic approach in COVID-19 patients.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Radiation Dosage
/
COVID-19
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Int J Radiat Biol
Journal subject:
Radiology
Year:
2021
Document Type:
Article
Affiliation country:
09553002.2021.1864049
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