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Replication, pathogenicity, and transmission of SARS-CoV-2 in minks.
Shuai, Lei; Zhong, Gongxun; Yuan, Quan; Wen, Zhiyuan; Wang, Chong; He, Xijun; Liu, Renqiang; Wang, Jinliang; Zhao, Qinjian; Liu, Yuxiu; Huo, Ningning; Deng, Junhua; Bai, Jingjing; Wu, Hongchao; Guan, Yuntao; Shi, Jianzhong; Tian, Kegong; Xia, Ningshao; Chen, Hualan; Bu, Zhigao.
  • Shuai L; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
  • Zhong G; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
  • Yuan Q; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen 361102, China.
  • Wen Z; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
  • Wang C; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
  • He X; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
  • Liu R; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
  • Wang J; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
  • Zhao Q; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen 361102, China.
  • Liu Y; National Research Center for Veterinary Medicine, Luoyang 471003, China.
  • Huo N; National Research Center for Veterinary Medicine, Luoyang 471003, China.
  • Deng J; National Research Center for Veterinary Medicine, Luoyang 471003, China.
  • Bai J; National Research Center for Veterinary Medicine, Luoyang 471003, China.
  • Wu H; National Research Center for Veterinary Medicine, Luoyang 471003, China.
  • Guan Y; National High Containment Laboratory for Animal Diseases Control and Prevention, Harbin 150069, China.
  • Shi J; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
  • Tian K; National Research Center for Veterinary Medicine, Luoyang 471003, China.
  • Xia N; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen 361102, China.
  • Chen H; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
  • Bu Z; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
Natl Sci Rev ; 8(3): nwaa291, 2021 Mar.
Article in English | MEDLINE | ID: covidwho-977391
ABSTRACT
Minks are raised in many countries and have transmitted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to humans. However, the biologic properties of SARS-CoV-2 in minks are largely unknown. Here, we investigated and found that SARS-CoV-2 replicates efficiently in both the upper and lower respiratory tracts, and transmits efficiently in minks via respiratory droplets; pulmonary lesions caused by SARS-CoV-2 in minks are similar to those seen in humans with COVID-19. We further found that a spike protein-based subunit vaccine largely prevented SARS-CoV-2 replication and lung damage caused by SARS-CoV-2 infection in minks. Our study indicates that minks are a useful animal model for evaluating the efficacy of drugs or vaccines against COVID-19 and that vaccination is a potential strategy to prevent minks from transmitting SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: Natl Sci Rev Year: 2021 Document Type: Article Affiliation country: Nsr

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: Natl Sci Rev Year: 2021 Document Type: Article Affiliation country: Nsr