Effects of vitamin D on macrophages and myeloid-derived suppressor cells (MDSCs) hyperinflammatory response in the lungs of COVID-19 patients.
Cell Immunol
; 360: 104259, 2021 02.
Article
in English
| MEDLINE | ID: covidwho-978233
ABSTRACT
Vitamin D regulates homeostasis, anti-microbial response, and inflammation. The vitamin D receptors are expressed in the macrophages and other immune cells, regulating the transcription of many different genes, including those coding the anti-microbial peptides. One of the most severe complications of the SARS-CoV-2 infection is the acute respiratory distress syndrome (ARDS) caused by the hyperinflammatory response (commonly called cytokine storm) of the lung macrophages. Studies showed that Vitamin D deficiency increases the severity of the ARDS in COVID-19 infection. We discuss here how the vitamin D supplementation may influence macrophage and myeloid-derived suppressor cells (MDSCs) inflammatory response, subdue the hyperinflammatory response, and lessen the ARDS in COVID-19 patients.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Vitamin D
/
Vitamins
/
COVID-19
/
COVID-19 Drug Treatment
/
Lung
Type of study:
Experimental Studies
/
Prognostic study
Topics:
Long Covid
Limits:
Animals
/
Child
/
Humans
Language:
English
Journal:
Cell Immunol
Year:
2021
Document Type:
Article
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