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Applications of Non-invasive Neuromodulation for the Management of Disorders Related to COVID-19.
Baptista, Abrahão Fontes; Baltar, Adriana; Okano, Alexandre Hideki; Moreira, Alexandre; Campos, Ana Carolina Pinheiro; Fernandes, Ana Mércia; Brunoni, André Russowsky; Badran, Bashar W; Tanaka, Clarice; de Andrade, Daniel Ciampi; da Silva Machado, Daniel Gomes; Morya, Edgard; Trujillo, Eduardo; Swami, Jaiti K; Camprodon, Joan A; Monte-Silva, Katia; Sá, Katia Nunes; Nunes, Isadora; Goulardins, Juliana Barbosa; Bikson, Marom; Sudbrack-Oliveira, Pedro; de Carvalho, Priscila; Duarte-Moreira, Rafael Jardim; Pagano, Rosana Lima; Shinjo, Samuel Katsuyuki; Zana, Yossi.
  • Baptista AF; Center for Mathematics, Computation and Cognition, Federal University of ABC, São Bernardo do Campo, Brazil.
  • Baltar A; NAPeN Network (Rede de Núcleos de Assistência e Pesquisa em Neuromodulação), Brazil.
  • Okano AH; Brazilian Institute of Neuroscience and Neurotechnology Centros de Pesquisa, Investigação e Difusão - Fundação de Amparo à Pesquisa do Estado de São Paulo (BRAINN/CEPID-FAPESP), University of Campinas, Campinas, Brazil.
  • Moreira A; Laboratory of Medical Investigations 54 (LIM-54), São Paulo University, São Paulo, Brazil.
  • Campos ACP; NAPeN Network (Rede de Núcleos de Assistência e Pesquisa em Neuromodulação), Brazil.
  • Fernandes AM; Specialized Neuromodulation Center-Neuromod, Recife, Brazil.
  • Brunoni AR; Center for Mathematics, Computation and Cognition, Federal University of ABC, São Bernardo do Campo, Brazil.
  • Badran BW; NAPeN Network (Rede de Núcleos de Assistência e Pesquisa em Neuromodulação), Brazil.
  • Tanaka C; Brazilian Institute of Neuroscience and Neurotechnology Centros de Pesquisa, Investigação e Difusão - Fundação de Amparo à Pesquisa do Estado de São Paulo (BRAINN/CEPID-FAPESP), University of Campinas, Campinas, Brazil.
  • de Andrade DC; Graduate Program in Physical Education, State University of Londrina, Londrina, Brazil.
  • da Silva Machado DG; School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
  • Morya E; Laboratory of Neuroscience, Hospital Sirio-Libanes, São Paulo, Brazil.
  • Trujillo E; Centro de Dor, LIM-62, Departamento de Neurologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.
  • Swami JK; Serviço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Instituto Nacional de Biomarcadores em Neuropsiquiatria, São Paulo, Brazil.
  • Camprodon JA; Instituto de Psiquiatria, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
  • Monte-Silva K; Department of Psychiatry, Medical University of South Carolina, Charleston, SC, United States.
  • Sá KN; NAPeN Network (Rede de Núcleos de Assistência e Pesquisa em Neuromodulação), Brazil.
  • Nunes I; Laboratory of Medical Investigations 54 (LIM-54), São Paulo University, São Paulo, Brazil.
  • Goulardins JB; Instituto Central, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
  • Bikson M; NAPeN Network (Rede de Núcleos de Assistência e Pesquisa em Neuromodulação), Brazil.
  • Sudbrack-Oliveira P; Centro de Dor, LIM-62, Departamento de Neurologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.
  • de Carvalho P; Graduate Program in Collective Health, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Duarte-Moreira RJ; Edmond and Lily Safra International Neuroscience Institute, Santos Dumont Institute, Macaiba, Brazil.
  • Pagano RL; Center for Mathematics, Computation and Cognition, Federal University of ABC, São Bernardo do Campo, Brazil.
  • Shinjo SK; NAPeN Network (Rede de Núcleos de Assistência e Pesquisa em Neuromodulação), Brazil.
  • Zana Y; Department of Biomedical Engineering, The City College of New York of CUNY, New York, NY, United States.
Front Neurol ; 11: 573718, 2020.
Article in English | MEDLINE | ID: covidwho-979025
ABSTRACT

Background:

Novel coronavirus disease (COVID-19) morbidity is not restricted to the respiratory system, but also affects the nervous system. Non-invasive neuromodulation may be useful in the treatment of the disorders associated with COVID-19.

Objective:

To describe the rationale and empirical basis of the use of non-invasive neuromodulation in the management of patients with COVID-10 and related disorders.

Methods:

We summarize COVID-19 pathophysiology with emphasis of direct neuroinvasiveness, neuroimmune response and inflammation, autonomic balance and neurological, musculoskeletal and neuropsychiatric sequela. This supports the development of a framework for advancing applications of non-invasive neuromodulation in the management COVID-19 and related disorders.

Results:

Non-invasive neuromodulation may manage disorders associated with COVID-19 through four pathways (1) Direct infection mitigation through the stimulation of regions involved in the regulation of systemic anti-inflammatory responses and/or autonomic responses and prevention of neuroinflammation and recovery of respiration; (2) Amelioration of COVID-19 symptoms of musculoskeletal pain and systemic fatigue; (3) Augmenting cognitive and physical rehabilitation following critical illness; and (4) Treating outbreak-related mental distress including neurological and psychiatric disorders exacerbated by surrounding psychosocial stressors related to COVID-19. The selection of the appropriate techniques will depend on the identified target treatment pathway.

Conclusion:

COVID-19 infection results in a myriad of acute and chronic symptoms, both directly associated with respiratory distress (e.g., rehabilitation) or of yet-to-be-determined etiology (e.g., fatigue). Non-invasive neuromodulation is a toolbox of techniques that based on targeted pathways and empirical evidence (largely in non-COVID-19 patients) can be investigated in the management of patients with COVID-19.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study Topics: Long Covid Language: English Journal: Front Neurol Year: 2020 Document Type: Article Affiliation country: Fneur.2020.573718

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study Topics: Long Covid Language: English Journal: Front Neurol Year: 2020 Document Type: Article Affiliation country: Fneur.2020.573718