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Unraveling the roles of vitamin D status and melanin during Covid­19 (Review).
Sidiropoulou, Polytimi; Docea, Anca Oana; Nikolaou, Vasiliki; Katsarou, Martha-Spyridoula; Spandidos, Demetrios A; Tsatsakis, Aristidis; Calina, Daniela; Drakoulis, Nikolaos.
  • Sidiropoulou P; 1st Department of Dermatology­Venereology, Faculty of Medicine, National and Kapodistrian University of Athens, 'A. Sygros' Hospital for Skin and Venereal Diseases, 16121 Athens, Greece.
  • Docea AO; Department of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
  • Nikolaou V; 1st Department of Dermatology­Venereology, Faculty of Medicine, National and Kapodistrian University of Athens, 'A. Sygros' Hospital for Skin and Venereal Diseases, 16121 Athens, Greece.
  • Katsarou MS; Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15771 Athens, Greece.
  • Spandidos DA; Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece.
  • Tsatsakis A; Department of Forensic Sciences and Toxicology, School of Medicine, University of Crete, 71003 Heraklion, Greece.
  • Calina D; Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
  • Drakoulis N; Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15771 Athens, Greece.
Int J Mol Med ; 47(1): 92-100, 2021 01.
Article in English | MEDLINE | ID: covidwho-979792
ABSTRACT
As the coronavirus disease 2019 (COVID­19) continues to spread worldwide, it has become evident that the morbidity and mortality rates clearly vary across nations. Although several factors may account for this disparity, striking differences within and between populations indicate that ethnicity might impact COVID­19 clinical outcomes, reflecting the 'color of disease'. Therefore, the role of key biological variables that could interplay with viral spreading and severity indices has attracted increasing attention, particularly among non­Caucasian populations. Although the links between vitamin D status and the incidence and severity of COVID-19 remain elusive, several lines of emerging evidence suggest that vitamin D signaling, targeting several immune­mediated pathways, may offer potential benefits at different stages of SARS-CoV-2 infection. Given that the vitamin D status is modulated by several intrinsic and extrinsic factors, including skin type (pigmentation), melanin polymers may also play a role in variable COVID­19 outcomes among diverse population settings. Moreover, apart from the well­known limiting effects of melanin on the endogenous production of vitamin D, the potential crosstalk between the pigmentary and immune system may also require special attention concerning the current pandemic. The present review article aimed to shed light on a range of mostly overlooked host factors, such as vitamin D status and melanin pigments, that may influence the course and outcome of COVID­19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vitamin D / Vitamin D Deficiency / Vitamins / Pandemics / SARS-CoV-2 / COVID-19 / Melanins Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Int J Mol Med Journal subject: Molecular Biology / Genetics, Medical Year: 2021 Document Type: Article Affiliation country: Ijmm.2020.4802

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vitamin D / Vitamin D Deficiency / Vitamins / Pandemics / SARS-CoV-2 / COVID-19 / Melanins Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Int J Mol Med Journal subject: Molecular Biology / Genetics, Medical Year: 2021 Document Type: Article Affiliation country: Ijmm.2020.4802