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Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications.
Mathew, Divij; Giles, Josephine R; Baxter, Amy E; Oldridge, Derek A; Greenplate, Allison R; Wu, Jennifer E; Alanio, Cécile; Kuri-Cervantes, Leticia; Pampena, M Betina; D'Andrea, Kurt; Manne, Sasikanth; Chen, Zeyu; Huang, Yinghui Jane; Reilly, John P; Weisman, Ariel R; Ittner, Caroline A G; Kuthuru, Oliva; Dougherty, Jeanette; Nzingha, Kito; Han, Nicholas; Kim, Justin; Pattekar, Ajinkya; Goodwin, Eileen C; Anderson, Elizabeth M; Weirick, Madison E; Gouma, Sigrid; Arevalo, Claudia P; Bolton, Marcus J; Chen, Fang; Lacey, Simon F; Ramage, Holly; Cherry, Sara; Hensley, Scott E; Apostolidis, Sokratis A; Huang, Alexander C; Vella, Laura A; Betts, Michael R; Meyer, Nuala J; Wherry, E John.
  • Mathew D; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Giles JR; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Baxter AE; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Oldridge DA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Greenplate AR; Parker Institute for Cancer Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Wu JE; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Alanio C; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Kuri-Cervantes L; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Pampena MB; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • D'Andrea K; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Manne S; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Chen Z; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Huang YJ; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Reilly JP; Parker Institute for Cancer Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Weisman AR; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Ittner CAG; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Kuthuru O; Parker Institute for Cancer Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Dougherty J; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Nzingha K; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Han N; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Kim J; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Pattekar A; Division of Translational Medicine and Human Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Goodwin EC; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Anderson EM; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Weirick ME; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Gouma S; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Arevalo CP; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Bolton MJ; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Chen F; Division of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Lacey SF; Division of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Ramage H; Division of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Cherry S; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Hensley SE; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Apostolidis SA; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Huang AC; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Vella LA; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Betts MR; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Meyer NJ; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Wherry EJ; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Science ; 369(6508)2020 09 04.
Article in English | MEDLINE | ID: covidwho-981641
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Immune response PROCESS_OF Homo sapiens
Subject
Immune response
Predicate
PROCESS_OF
Object
Homo sapiens
3. T-Cell Activation PROCESS_OF Patients
Subject
T-Cell Activation
Predicate
PROCESS_OF
Object
Patients
4. Vaccines TREATS COVID-19
Subject
Vaccines
Predicate
TREATS
Object
COVID-19
5. Therapeutic procedure TREATS COVID-19
Subject
Therapeutic procedure
Predicate
TREATS
Object
COVID-19
6. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
7. Immune response PROCESS_OF Homo sapiens
Subject
Immune response
Predicate
PROCESS_OF
Object
Homo sapiens
8. T-Cell Activation PROCESS_OF Patients
Subject
T-Cell Activation
Predicate
PROCESS_OF
Object
Patients
9. Vaccines TREATS COVID-19
Subject
Vaccines
Predicate
TREATS
Object
COVID-19
10. Therapeutic procedure TREATS COVID-19
Subject
Therapeutic procedure
Predicate
TREATS
Object
COVID-19
ABSTRACT
Coronavirus disease 2019 (COVID-19) is currently a global pandemic, but human immune responses to the virus remain poorly understood. We used high-dimensional cytometry to analyze 125 COVID-19 patients and compare them with recovered and healthy individuals. Integrated analysis of ~200 immune and ~50 clinical features revealed activation of T cell and B cell subsets in a proportion of patients. A subgroup of patients had T cell activation characteristic of acute viral infection and plasmablast responses reaching >30% of circulating B cells. However, another subgroup had lymphocyte activation comparable with that in uninfected individuals. Stable versus dynamic immunological signatures were identified and linked to trajectories of disease severity change. Our analyses identified three immunotypes associated with poor clinical trajectories versus improving health. These immunotypes may have implications for the design of therapeutics and vaccines for COVID-19.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / B-Lymphocytes / T-Lymphocytes / Coronavirus Infections / Betacoronavirus Type of study: Prognostic study Topics: Vaccines Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Year: 2020 Document Type: Article Affiliation country: Science.abc8511

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / B-Lymphocytes / T-Lymphocytes / Coronavirus Infections / Betacoronavirus Type of study: Prognostic study Topics: Vaccines Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Year: 2020 Document Type: Article Affiliation country: Science.abc8511