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Cardiovascular Disease and SARS-CoV-2: the Role of Host Immune Response Versus Direct Viral Injury.
Biscetti, Federico; Rando, Maria Margherita; Nardella, Elisabetta; Cecchini, Andrea Leonardo; Bruno, Piergiorgio; Landolfi, Raffaele; Flex, Andrea.
  • Biscetti F; Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy.
  • Rando MM; Internal Medicine and Vascular Diseases Unit, 00168 Roma, Italy.
  • Nardella E; Laboratory of Vascular Biology and Genetics, Department of Translational Medicine and Surgery, 00168 Roma, Italy.
  • Cecchini AL; Internal Medicine and Vascular Diseases Unit, 00168 Roma, Italy.
  • Bruno P; Internal Medicine and Vascular Diseases Unit, 00168 Roma, Italy.
  • Landolfi R; Internal Medicine and Vascular Diseases Unit, 00168 Roma, Italy.
  • Flex A; Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy.
Int J Mol Sci ; 21(21)2020 Oct 30.
Article in English | MEDLINE | ID: covidwho-983342
ABSTRACT
The 2019 novel coronavirus [2019-nCoV], which started to spread from December 2019 onwards, caused a global pandemic. Besides being responsible for the severe acute respiratory syndrome 2 [SARS-CoV-2], the virus can affect other organs causing various symptoms. A close relationship between SARS-CoV-2 and the cardiovascular system has been shown, demonstrating an epidemiological linkage between SARS-CoV-2 and cardiac injury. There are emerging data regarding possible direct myocardial damage by 2019-nCoV. In this review, the most important available evidences will be discussed to clarify the precise mechanisms of cardiovascular injury in SARS-CoV-2 patients, even if further researches are needed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cardiovascular Diseases / Coronavirus Infections Type of study: Observational study Topics: Long Covid Limits: Animals / Humans Language: English Year: 2020 Document Type: Article Affiliation country: Ijms21218141

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cardiovascular Diseases / Coronavirus Infections Type of study: Observational study Topics: Long Covid Limits: Animals / Humans Language: English Year: 2020 Document Type: Article Affiliation country: Ijms21218141