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Analyses of abdominal adiposity and metabolic syndrome as risk factors for respiratory distress in COVID-19.
van Zelst, Cathelijne M; Janssen, Matthijs L; Pouw, Nadine; Birnie, Erwin; Castro Cabezas, Manuel; Braunstahl, Gert-Jan.
  • van Zelst CM; Pulmonology, Franciscus Gasthuis en Vlietland, Rotterdam, Zuid-Holland, The Netherlands c.vanzelst@erasmusmc.nl.
  • Janssen ML; Department of Pulmonology, Erasmus Medical Center, Rotterdam, Zuid-Holland, The Netherlands.
  • Pouw N; Department of Pulmonology, Erasmus Medical Center, Rotterdam, Zuid-Holland, The Netherlands.
  • Birnie E; Internal Medicine, Franciscus Gasthuis en Vlietland, Rotterdam, Zuid-Holland, The Netherlands.
  • Castro Cabezas M; Department of Clinical Chemistry, Franciscus Gasthuis en Vlietland, Rotterdam, Zuid-Holland, The Netherlands.
  • Braunstahl GJ; Department of Statistics and Education, Franciscus Gasthuis en Vlietland, Rotterdam, Zuid-Holland, The Netherlands.
BMJ Open Respir Res ; 7(1)2020 12.
Article in English | MEDLINE | ID: covidwho-983651
ABSTRACT

BACKGROUND:

Several characteristics of the metabolic syndrome, such as obesity and hypertension, have emerged as risk factors for a poor clinical outcome in COVID-19. However, most reports lack data on the metabolic syndrome itself. This study investigated prospectively the relationship between respiratory deterioration and the presence of metabolic syndrome or abdominal adiposity in patients with COVID-19.

METHODS:

A prospective observational cohort study analysing patients with respiratory symptoms who presented at a local emergency department in the Netherlands. The influence of abdominal adiposity-assessed by an increased waist-hip ratio-and metabolic syndrome on respiratory deterioration and the length of hospital stay were analysed with multivariable logistic regressions and Kaplan-Meier analyses.

RESULTS:

In total, 166 patients were analysed, of whom 86 (52%) tested positive for COVID-19. The prevalence of metabolic syndrome did not differ between patients with COVID-19 with and without the need for intubation or level of supportive care (37.5% vs 48.4%, p=0.338). In contrast, abdominal adiposity is an independent risk factor for respiratory distress in COVID-19, adjusted for metabolic syndrome, age, gender and BMI (OR 1.11, 95% CI 1.02 to 1.20, p=0.014).

CONCLUSION:

This study shows that abdominal adiposity, and not the presence of metabolic syndrome, is associated with clinical deterioration in COVID-19. This prospective study provides further insight into the risk stratification of patients with COVID-19 based on a simple measurement as the waist and hip circumference. TRIAL REGISTRATION NUMBER NL8580.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Metabolic Syndrome / Obesity, Abdominal / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Year: 2020 Document Type: Article Affiliation country: Bmjresp-2020-000792

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / Metabolic Syndrome / Obesity, Abdominal / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Year: 2020 Document Type: Article Affiliation country: Bmjresp-2020-000792